威海地区女性不孕症患者解脲脲原体、沙眼衣原体感染状况调查

发布时间：2018-04-03 12:43

  本文选题：解脲脲原体　切入点：沙眼衣原体　出处：《青岛大学》2014年硕士论文

【摘要】：目的检测威海地区女性不孕症患者解脲脲原体(ureaplasma urealyticum, UU)和沙眼衣原体(chlamydia trachomatis, CT)的感染状况,以探讨UU、CT感染与女性不孕的相关性。 方法选取2013年1月到12月在威海市妇幼保健院生殖医学门诊就诊的女性不孕症患者731例为不孕组,同期在体检中心查体的已生育健康女性200例做为对照组,采集宫颈分泌物标本,应用实时荧光定量PCR(TaqMan PCR)行UU-DNA、CT-DNA定量检测。 结果(1)不孕症病因分析：731位不孕症患者中以输卵管性不孕最多,占49.7%,排卵异常、子宫内膜异位症、免疫性不孕患者及其他病因患者分别占32.4%、5.6%、8.2%和4.1%。(2)不孕组UU、CT及UU+CT的感染率分别为53.9%(394/731)、29.8%(218/731)和12.6%(92/731),对照组为24%(48/200)、17.5%(35/200)和5%(10/200),均有显著性差异(P0.001)。(3)年龄分布：731例患者中26-30岁年龄组的UU、CT、UU+CT的感染率最高分别占25.2%、15.3%、7.3%；31-35岁年龄组次之,分别占16.8%、12.2%、4.4%；20-25岁年龄组分别占3.4%、0.8%、0.4%；36-40岁年龄组分别占6.3%、1.1%、0.4%；41-45岁年龄组分别占2.2%、0.4%、0.1%。结论威海地区女性不孕患者UU、CT、UU+CT阳性率明显高于正常女性,表明UU、CT感染与女性不孕有一定的相关性；UU、CT检测应成为不孕症的常规实验室检查项目。
[Abstract]:Objective to detect the infection of Ureaplasma Urealyticum (UUU) and chlamydia trachomatis( CTT) in female infertility patients in Weihai area, and to explore the correlation between UUCT infection and female infertility.Methods from January to December 2013, 731 female infertility patients were selected as infertile group and 200 healthy women who had been examined in the physical examination center were selected as the control group in the reproductive medicine outpatient clinic of Weihai Maternal and Child Health Hospital from January to December 2013.The samples of cervical secretions were collected and the UU-DNA CT-DNA quantitative detection was performed by real-time fluorescence quantitative PCR(TaqMan.Results 1) Analysis of the etiology of infertility; among the 731 infertility patients, oviduct infertility was the most common, accounting for 49.7%, ovulation abnormality, endometriosis,鍏嶇柅鎬т笉瀛曟偅鑰呭強鍏朵粬鐥呭洜鎮ｈ，

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