GnRH激动剂对滋养细胞肿瘤化疗患者卵巢储备功能的影响

发布时间：2018-04-04 04:48

本文选题：GnRH激动剂　切入点：滋养细胞肿瘤　出处：《广东医学》2015年14期

【摘要】：目的研究和评价GnRH激动剂对妊娠滋养细胞肿瘤化疗患者卵巢储备功能的保护作用。方法选取接受化疗的低危初治滋养细胞肿瘤患者57例,随机分为观察组(n=29)和对照组(n=28)。观察组在化疗开始前给予GnRH激动剂至化疗结束,对照组不给予GnRH激动剂,观察并比较两组患者化疗前、化疗结束后1年的窦卵泡计数、抗苗勒氏管激素(AMH)和卵泡刺激素(FSH)水平。结果两组患者化疗疗程数比较差异无统计学意义(P0.05),观察组化疗前后窦卵泡计数、AMH和FSH水平比较差异无统计学意义(P0.05)。对照组化疗前后窦卵泡计数、AMH和FSH水平比较差异有统计学意义(P0.05)。化疗结束后1年观察组窦卵泡计数、AMH、FSH水平均显著优于对照组(P0.05)。结论 GnRHa的应用没有降低化疗疗效、增加化疗疗程,同时对滋养细胞肿瘤化疗患者的卵巢储备功能有一定的保护作用。
[Abstract]:Objective to study and evaluate the protective effect of GnRH agonist on ovarian reserve in patients with gestational trophoblastic tumor.Methods Fifty-seven patients with low-risk primary trophoblastic tumor who received chemotherapy were randomly divided into observation group (n = 29) and control group (n = 28).GnRH agonists were given to the experimental group before the beginning of chemotherapy until the end of chemotherapy, while the GnRH agonists were not given to the control group. The antral follicle count, anti-Mullerian canal hormone (GnRH) and follicle stimulating hormone (FSH) levels were observed and compared between the two groups before chemotherapy and one year after chemotherapy.Results there was no significant difference in the number of courses of chemotherapy between the two groups (P 0.05). There was no significant difference in antral follicle count and FSH levels between the two groups before and after chemotherapy.In the control group, the levels of AMH and FSH in antral follicle count before and after chemotherapy were significantly different (P 0.05).One year after chemotherapy, the antral follicle count and AMH FSH in the observation group were significantly higher than those in the control group (P 0.05).Conclusion the application of GnRHa does not decrease the curative effect of chemotherapy, increase the course of chemotherapy, and protect the ovarian reserve function of trophoblastic tumor patients.
【作者单位】：福建省立医院妇产科;
【分类号】：R737.33

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