安徽5县农村女性HPV感染及宫颈病变分析

发布时间：2018-04-06 05:32

本文选题：人乳头瘤病毒　切入点：感染　出处：《中国公共卫生》2016年04期

【摘要】：目的了解5个县农村女性人乳头瘤病毒(HPV)感染与宫颈病变分布特征,探讨宫颈癌防治对策。方法 2014年在安徽省5个县抽取21 078名35~64岁农村妇女,进行高危亚型/高危分型HPV初筛,并根据HPV初筛结果进行宫颈细胞学、阴道镜、病理等进一步检查,分析HPV感染状况和型别以及病理检查结果。结果21 078名妇女HPV初筛阳性检出率为8.01%,其中检出率最高的16型占18.41%;5个县中HPV初筛阳性检出率为6.06%~9.43%,且各县6种常见型别HPV检出率排序不同,差异均有统计学意义;35~39岁HPV初筛阳性检出率最低,为6.90%,55~65岁最高,为8.94%,随着年龄增加检出率呈现上升趋势(P0.05);HPV检测对于识别宫颈病变具有较高的灵敏度和阳性预测值,分别为98.44%和89.74%;HPV检测对于识别宫颈癌及癌前病变灵敏度和阴性预测值均为100.00%;宫颈癌和癌前病变检出率为488.66/10万,HPV初筛结果阳性者中宫颈癌和癌前病变检出率为9.18%。结论安徽省5县HPV检出率存在地区差异,HPV检出率随年龄增长而增加,HPV初筛有助于宫颈早期病变的早发现和早干预。
[Abstract]:Objective to investigate the distribution of HPV infection and cervical lesions in rural women in five counties, and to explore the prevention and treatment of cervical cancer.Methods 21,078 rural women aged 35 to 64 years were selected from 5 counties of Anhui Province in 2014, and were screened for HPV with high risk subtype / high risk typing. According to the results of HPV screening, cervical cytology, colposcopy and pathology were further examined.The infection status and type of HPV and pathological examination results were analyzed.Results the positive rate of primary screening of HPV was 8.01 in 21 078 women, and the highest positive rate of 16 type was 18.41, and the positive rate of primary screening of HPV was 6.06% 9.43% in 5 counties, and the order of HPV detection rate of 6 common types of HPV was different in each county.The difference was statistically significant (P < 0.05). The detection rate of HPV in primary screening was the lowest at the age of 6.90555, the highest was 8.94. with the increase of age, the detection rate of P0.05HPVP had a high sensitivity and positive predictive value for the identification of cervical lesions.The sensitivity and negative predictive value of HPV detection in identifying cervical cancer and precancerous lesions were 98.44% and 89.74%, respectively, and the positive rate of cervical cancer and precancerous lesions was 9.18%.Conclusion there are regional differences in the detection rate of HPV in 5 counties in Anhui Province. The increase of HPV detection rate with age is helpful to the early detection and early intervention of cervical early lesions.
【作者单位】：安徽省妇幼保健所;安徽省卫生计生委妇幼健康服务处;
【分类号】：R737.33

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