垂体降调节对不明原因反复种植失败患者冻融胚胎移植周期的影响

发布时间：2018-04-08 10:59

本文选题：不明原因反复种植失败　切入点：冻融胚胎移植　出处：《实用妇产科杂志》2017年05期

【摘要】：目的:探讨垂体降调节后激素替代方案对不明原因反复种植失败(RIF)患者冻融胚胎移植周期的影响。方法:回顾性分析2012年1月至2015年12月在中山大学附属第六医院生殖中心使用垂体降调方案进行冻融胚胎移植的不明原因RIF患者118例的291个冻融周期。其中GnRH-a垂体降调节周期131个周期(A组,118例),非降调周期160个周期(B组,95例)。比较两组基本情况、周期特点及周期妊娠结局的差异。结果:A组患者的既往冷冻周期数高于B组(2.40±0.10个vs1.76±0.07个),差异有统计学意义(P0.01),而两组的年龄、不孕类型、不孕年限、BMI、基础FSH、窦卵泡数及移植胚胎数、优质胚胎率、转化日或排卵日内膜厚度比较,差异均无统计学意义(P0.05);A组患者的种植率、生化妊娠率、临床妊娠率及持续妊娠率均高于B组,差异有统计学意义(P0.01),A组患者流产率低于B组,差异有统计学意义(P0.01)。结论:对不明原因RIF不孕患者,在冻融胚胎移植周期使用垂体降调节方案有望改善此类患者的助孕治疗结局。
[Abstract]:Aim: to investigate the effect of hypophyseal postganglionic hormone replacement on frozen and thawed embryo transfer cycle in patients with RIFs.Methods: the 291 freeze-thaw cycles of 118 patients with unexplained RIF were retrospectively analyzed from January 2012 to December 2015 in the Reproductive Center of sixth affiliated Hospital of Sun Yat-sen University.There were 118 cases in group A and 95 cases in group B in group A and group B, respectively.The basic condition, cycle characteristics and pregnancy outcome were compared between the two groups.There was no significant difference in the thickness of endometrium on the conversion day or ovulation day. The implantation rate, biochemical pregnancy rate, clinical pregnancy rate and continuous pregnancy rate in group A were significantly higher than those in group B, and the abortion rate in group A was lower than that in group B.The difference was statistically significant (P 0.01).Conclusion: for patients with unexplained RIF infertility, the use of hypophyseal hypophysis regulation in the frozen-thawed embryo transfer cycle is expected to improve the outcome of pregnancy aid therapy in these patients.
【作者单位】：中山大学附属第六医院;
【基金】：国家自然科学基金(编号:81470063) 广东省自然科学基金(编号:2014A030313129) 广东省医学科学技术研究基金(编号:A2015025)
【分类号】：R714.8

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