妊娠晚期孕妇B族溶血性链球菌感染对孕产妇凝血功能及母婴结局的影响

发布时间：2018-04-09 04:17

本文选题：妊娠晚期　切入点：B族溶血性链球菌　出处：《中华医院感染学杂志》2017年19期

【摘要】：目的探究妊娠晚期孕妇B族溶血性链球菌感染对孕产妇凝血功能及母婴结局的影响。方法选择2014年12月-2015年10月在医院产检的孕妇320例,均经B超检查进行确认、核对,依据孕妇是否存在B族溶血性链球菌感染将其划分为B族溶血性链球菌感染阳性组29例,阴性组58例(依据其就诊时ID号码,从291例B族溶血性链球菌阴性的产妇中随机选择58例),观察凝血功能及母婴结局。结果 320例孕妇中检测出B族溶血性链球菌感染阳性患者29例,阳性率为9.06%;阳性组除血浆凝血酶时间(TT)外,血浆凝血酶原时间(PT)(9.67±1.13)s、国际标准化比率(INR)(0.95±0.07)及活化部分凝血活酶时间(APTT)(25.69±3.65)s与阴性组比较均明显缩短,而纤维蛋白原(Fbg)(3.89±1.68)g/L与阴性组比较明显增高(P0.05);29例感染阳性孕妇中2例发生胎膜早破,发生率6.90%,58例阴性孕妇中3例发生胎膜早破,发生率5.17%,两组无统计学差异;阳性组孕妇剖宫产率和胎儿窘迫发生率、新生儿窒息发生率和病理学黄疸发生率,明显高于阴性组(P0.05)。结论密切观察B族溶血性链球菌感染孕妇的凝血功能情况,可在一定程度上预防弥散性血管内凝血(DIC)出血性疾病,同时对妊娠晚期孕妇给予适量抗菌药物,对于降低妊娠孕妇和新生儿相关并发症,保证孕妇和新生儿的生命安全具有重要意义。
[Abstract]:Objective to investigate the effect of group B hemolytic streptococcus infection on coagulation function and maternal and infant outcome of pregnant women in the third trimester of pregnancy.Methods 320 pregnant women born in hospital from December 2014 to October 2015 were selected and confirmed by B-ultrasound. According to whether the pregnant women had Group B hemolytic streptococcus infection, they were divided into 29 cases of Group B hemolytic Streptococcus infection positive group.58 cases of negative group (according to their ID number) were randomly selected from 291 cases of group B hemolytic streptococcus negative puerpera to observe the coagulation function and the outcome of mother and child.Results 29 cases of Group B hemolytic streptococcus infection were detected in 320 pregnant women, the positive rate was 9.06.The positive group except plasma thrombin time (TTT),The incidence of premature rupture of membranes in 3 out of 58 negative pregnant women was 5.170.There was no statistical difference between the two groups, and the rate of cesarean section, fetal distress, neonatal asphyxia and pathological jaundice in the positive group was significantly higher than that in the negative group (P 0.05).Conclusion to observe the coagulation function of pregnant women with B group hemolytic streptococcus infection can prevent the disseminated intravascular coagulation (DICD) hemorrhagic disease to some extent, and at the same time, give appropriate amount of antibiotics to the pregnant women in the third trimester of pregnancy.It is of great significance to reduce the complications of pregnant women and newborns and to ensure the safety of pregnant women and newborns.
【作者单位】：儋州市人口和计划生育服务中心;儋州市妇幼保健院妇产科;
【分类号】：R714.251

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