羊水过多产前诊断及妊娠结局分析

发布时间：2018-04-09 19:00

本文选题：羊水过多　切入点：产前诊断　出处：《中国妇幼保健》2015年02期

【摘要】：目的:通过对妊娠期羊水过多的孕妇进行产前诊断及妊娠结局分析,探讨羊水过多的病因及妊娠结局情况。方法:选取2008年7月~2013年7月在广西医科大学第一附属医院产前诊断中心就诊的孕17~32周的50例羊水过多孕妇为病例组,同期羊水量正常孕妇80例为对照组。分析羊水过多的病因,对羊水过多孕妇行羊水或脐带血胎儿染色体核型分析,并对地中海贫血基因携带者行羊水或脐带血基因分析,随访记录及分析比较两组的妊娠结局。结果:病例组羊水过多的病因中,不明原因占44.0%,染色体异常占4.0%,重型α地中海贫血占14.0%,胎儿畸形占30.0%,母胎疾病占8.0%。与对照组相比,病例组的剖宫产率、早产率、胎儿畸形率、胎儿窘迫率、巨大胎儿发生率及胎儿为女性比率均增高,差异有统计学意义(P0.05)。结论:羊水过多与胎儿畸形、胎儿染色体异常和胎儿重型α地中海贫血有一定关系,但仍有约1/3病例病因不明;羊水过多的妊娠结局较差,有必要对羊水过多孕妇加强孕期母胎监测及进行胎儿产前诊断。
[Abstract]:Objective: to study the etiology and pregnancy outcome of amniotic fluid hyperhydramnios by prenatal diagnosis and pregnancy outcome analysis.Methods: from July 2008 to July 2013, 50 pregnant women with amniotic fluid hyperhydramnios were selected from the antenatal diagnosis center of the first affiliated Hospital of Guangxi Medical University as the case group, and 80 normal amniotic fluid pregnant women as the control group.The causes of amniotic fluid hyperhydramnios were analyzed. The fetal chromosomal karyotype of amniotic fluid or umbilical cord blood was analyzed for the pregnant women with amniotic fluid and the gene analysis of amniotic fluid or umbilical cord blood in the carriers of thalassemia gene. The pregnancy outcomes of the two groups were recorded and analyzed.Results: among the causes of amniotic fluid hyperhydramnios in the case group, unknown cause was 44.0, chromosome abnormality was 4.0, severe 伪 thalassemia was 14.0, fetal malformation was 30.0, maternal and fetal diseases were 8.0.Compared with the control group, the cesarean section rate, premature delivery rate, fetal malformation rate, fetal distress rate, fetal macrosomia rate and fetal female ratio in the case group were higher than those in the control group, and the difference was statistically significant (P 0.05).Conclusion: amniotic fluid excess is associated with fetal malformation, fetal chromosome abnormality and fetal severe 伪 -thalassemia, but there are still about one third of the cases with unknown etiology, and the pregnancy outcome of amniotic fluid excess is poor.It is necessary for pregnant women with amniotic fluid to strengthen maternal and fetal monitoring and prenatal diagnosis.
【作者单位】：广西医科大学第一附属医院妇产科;
【基金】：广西自然科学基金〔2014GXNSFAA118246〕广西卫生厅自筹基金项目〔Z2014042〕
【分类号】：R714.5

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