CD44v6及c-met在子宫内膜样腺癌中的表达及意义

发布时间：2018-04-12 20:55

本文选题：CD44v6 + c-met　；参考：《南昌大学》2014年硕士论文

【摘要】：目的：通过检测正常子宫内膜、不典型增生子宫内膜及子宫内膜样腺癌中CD44v6、c-met的表达水平，分析两者在子宫内膜样腺癌中表达及与临床病理的关系,探讨两者在子宫内膜样腺癌发生及发展过程中的作用。方法：查阅病例资料，选取在我院手术治疗的子宫内膜样腺癌患者癌组织石蜡标本69例，同期不典型增生子宫内膜30例，正常子宫内膜20例，应用免疫组织化学MaxVision法检测c-met、CD44v6在三组中的表达情况。结果： 1.CD44v6在正常子宫内膜、不典型增生子宫内膜、子宫内膜样腺癌组织中的阳性表达率分别为25.0%、40.0%、85.5%，三组之间CD44v6表达差异具有统计学意义(P＜0.05）；在I期、II期、III-IV期子宫内膜样腺癌组织中，CD44v6阳性表达率分别为78.94%、84.62%、91.67%，差异显著((P＜0.05)；在1/2肌层浸润癌组织及"g1/2肌层浸润癌组织中，CD44v6阳性表达率分别75.86%、92.50%，差异具有统计学意义(P＜0.05)；而在不同分化程度和有无淋巴结转移的子宫内膜样腺癌组织中，CD44v6阳性表达差异无统计学意义(P＞0.05)。 2.c-met在正常子宫内膜、不典型增生子宫内膜、子宫内膜样腺癌中阳性表达率分别为15%、36.67%、52.17%，c-met表达差异具有统计学意义(P0.05)；在I期、II期、III-IV期子宫内膜样腺癌组织中，c-met阳性表达率分别为36.84%、50.0%、66.67%，差异有统计学意义(P＜0.05)。而在不同分化程度、不同肌层浸润深度及有无淋巴结转移的子宫内膜样腺癌组织中，c-met表达差异无统计学意义（P＞0.05）。 3.在子宫内膜样腺癌组织中CD44v6与c-met的表达无明显相关性（r=-0.145，P=0.222）。结论 1．CD44v6在正常子宫内膜、不典型增生子宫内膜、子宫内膜样腺癌中表达呈递增趋势，并且与临床分期及肌层浸润深度呈正相关，提示CD44v6可能参与了子宫内膜样腺癌的发生、发展、浸润过程的调节； 2．c-met在正常子宫内膜、不典型增生子宫内膜、子宫内膜样腺癌中表达呈递增趋势，与临床分期呈正相关，但与病理分级、肌层深度及淋巴结转移无相关性，提示c-met可能参与了子宫内膜样腺癌的发生、发展等过程调节； 3．CD44v6和c-met之间无明显的相关性，，提示两者可能在调节子宫内膜样腺癌的发生及发展过程中独自发挥作用，或仅存在少许关联。
[Abstract]:Objective:By detecting the expression of CD44v6 c-met in normal endometrium, atypical hyperplasia endometrium and endometrial adenocarcinoma, the relationship between the expression of CD44v6 and c-met in endometrioid adenocarcinoma and clinicopathology was analyzed.To explore the role of both in the occurrence and development of endometrial adenocarcinoma.Methods:According to the data of the cases, 69 cases of endometrial adenocarcinoma, 30 cases of atypical hyperplasia of endometrium and 20 cases of normal endometrium were selected from cancer tissues of patients with endometrial adenocarcinoma treated in our hospital.Immunohistochemical MaxVision method was used to detect the expression of c-metamer CD44v6 in the three groups.Results:1.CD44v6 in normal endometrium, atypical hyperplasia of endometrium,The positive expression rates of CD44v6 in 1 / 2 myometrial infiltrating carcinoma and "g1 / 2 muscular infiltrating carcinoma" were 75.86 and 92.50, respectively. The difference was statistically significant (P < 0.05), but the positive expression of CD44v6 was poor in endometrial adenocarcinoma with or without lymph node metastasis.There was no statistical significance (P > 0.05).2.c-met in normal endometrium, atypical hyperplasia of endometrium,However, there was no significant difference in the expression of c-met in endometrioid adenocarcinoma with different differentiation degree, depth of myometrial invasion and lymph node metastasis (P > 0.05).3.There was no significant correlation between the expression of CD44v6 and c-met in endometrial adenocarcinoma.ConclusionThe expression of 1.CD44v6 in normal endometrium, atypical hyperplasia endometrium and endometrioid adenocarcinoma showed an increasing trend, and was positively correlated with clinical stage and depth of myometrium invasion, suggesting that CD44v6 may be involved in the occurrence and development of endometrioid adenocarcinoma.The regulation of infiltration process;The expression of 2.c-met in normal endometrium, atypical hyperplasia endometrium and endometrioid adenocarcinoma showed an increasing trend, which was positively correlated with clinical stage, but had no correlation with pathological grade, myometrial depth and lymph node metastasis.The results suggest that c-met may play a role in the pathogenesis and development of endometrial adenocarcinoma.There is no significant correlation between 3.CD44v6 and c-met, suggesting that they may play a separate role in the regulation of the occurrence and development of endometrial adenocarcinoma.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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