养血复宫丸治疗血瘀型剖宫产产后恶露不绝的临床研究

发布时间：2018-04-12 21:47

本文选题：养血复宫丸 + 血瘀型　；参考：《山东中医药大学》2017年硕士论文

【摘要】：目的:观察养血复宫丸对血瘀型剖宫产产后恶露不绝患者的临床疗效,为养血复宫丸的临床应用提供科学依据。方法:收集自2015年1月~2016年1月期间济宁市中医院门诊和住院的符合临床诊断标准的行剖宫产手术产妇产后恶露不绝患者92例,依据随机数字表法随机分为治疗组46例与对照组46例。对照组采用新生化颗粒温水冲服,一次2袋×6g,每日3次;治疗组使用济宁市中医院院内制剂养血复宫丸进行治疗,口服,一次9g,每日3次。两组疗程均以7d为1疗程,连续给药2个疗程。比较两组治疗后疾病疗效、中医证候疗效,治疗前后证候积分、不同年龄段治疗前后中医证候积分、不同治疗阶段中医证候积分、各分项证候积分、子宫体积变化、血红蛋白、红细胞、血浆黏度、血沉、纤维蛋白原变化及用药期间不良反应发生情况。结果:(1)治疗组疾病总有效率(95.65%)高于对照组(78.26%),且具有统计学差异(P0.05);(2)治疗组证候总有效率(93.48%)高于对照组(76.09%),且具有统计学差异(P0.05);(3)两组证候积分治疗后明显下降,且具有统计学差异(P0.05);治疗组证候积分治疗后明显低于对照组,且具有统计学差异(P0.05);(4)两组不同年龄段证候积分治疗后明显降低,且具有统计学差异(P0.05);治疗组不同年龄段证候积分治疗后明显低于对照组,且具有统计学差异(P0.05);而两组不同年龄段证候积分治疗后组内比较无统计学差异(P0.05);(5)两组治疗2个疗程证候积分较治疗1个疗程明显降低,且具有统计学差异(P0.05);治疗组治疗1个疗程和治疗2个疗程证候积分均明显低于对照组,且具有统计学差异(P0.05);(6)两组持续时间、血量、血色、血质、小腹疼痛积分治疗后明显下降,且具有统计学差异(P0.05);治疗组持续时间、血量、血色、血质、小腹疼痛积分治疗后低于对照组,且具有统计学差异(P0.05);(7)两组子宫体积治疗后明显降低,且具有统计学差异(P0.05);治疗组子宫体积治疗后明显低于对照组,且具有统计学差异(P0.05);(8)两组血浆黏度、血沉、纤维蛋白原治疗后较治疗前下降,且具有统计学差异(P0.05);治疗组血浆黏度、血沉、纤维蛋白原治疗后低于对照组,且具有统计学差异(P0.05);(9)两组均未见严重用药不良反应。结论:养血复宫丸治疗血瘀型剖宫产产后恶露不绝患者疗效显著,可明显改善患者证候,可明显降低患者子宫体积,且可降低血浆黏度、血沉、纤维蛋白原,安全可靠,具有重要研究价值,值得临床进一步推广应用。
[Abstract]:Objective: to observe the clinical effect of Yangxue Fugong Pill on postpartum lochia caused by blood stasis type cesarean section, and to provide scientific basis for clinical application of Yangxue Fugong Pill.Methods: from January 2015 to January 2016, 92 patients with postpartum lochia in accordance with clinical diagnosis criteria were collected.According to the method of random digital table, 46 cases in treatment group and 46 cases in control group were randomly divided into treatment group and control group.The control group was treated with warm water, 2 bags 脳 6 g, 3 times a day, and the treatment group was treated with Yangxue Fugong pill, which was used in hospital of Jining City traditional Chinese Medicine Hospital, orally, 9 g once a day, 3 times a day.The course of treatment in both groups was 7 days as a course of treatment and 2 consecutive courses of administration.Compare the curative effect of the two groups after treatment, the curative effect of TCM syndrome, the integral of syndrome before and after treatment, the integral of TCM syndrome before and after treatment at different ages, the integral of TCM syndrome in different treatment stage, the integral of syndrome of each item, the change of uterine volume, the hemoglobin,Red blood cells, plasma viscosity, erythrocyte sedimentation rate, fibrinogen changes and adverse reactions during medication.Results the total effective rate of disease in the treatment group (95.65) was higher than that in the control group (78.26), and the difference was statistically significant (P 0.05). The total effective rate of syndromes in the treatment group was 93.48) higher than that in the control group (76.09%), and the difference was statistically significant (P 0.05).After treatment, the syndromes integral in the treatment group was significantly lower than that in the control group, and there was a statistical difference between the two groups.And there was statistical difference (P 0.05), the syndrome integral of different ages in the treatment group was significantly lower than that in the control group.There was no statistical difference between the two groups after the treatment of syndromes of different age groups (P0.05) the scores of two courses of treatment were significantly lower than that of one course of treatment, and there was no statistical difference between the two groups after treatment.The results showed that the duration, blood volume, blood color, blood quality and abdominal pain score in the treatment group were lower than those in the control group, and the uterine volume in the treatment group was significantly lower than that in the control group (P 0.05), and the uterine volume in the treatment group was significantly lower than that in the control group (P < 0.05).The uterine volume in the treatment group was significantly lower than that in the control group (P 0.05), and the plasma viscosity, erythrocyte sedimentation rate (ESR) and fibrinogen (Fibrinogen) in the two groups were decreased after treatment.The plasma viscosity, erythrocyte sedimentation rate and fibrinogen in the treatment group were lower than those in the control group, and there was no serious adverse drug reaction between the two groups.Conclusion: Yangxue Fugong pills has a significant effect on the treatment of postpartum lochia caused by blood stasis type cesarean section. It can obviously improve the syndromes of the patients, reduce the volume of uterus, and reduce the plasma viscosity, erythrocyte sedimentation rate, fibrinogen, and is safe and reliable.It has important research value and is worthy of further clinical application.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R719.8

【参考文献】