广东人类精子库生殖保险及临床应用13年回顾性分析

发布时间：2018-04-14 01:01

  本文选题：生殖保险 + 自精保存　； 参考：《广东医学》2017年05期

【摘要】：目的分析广东省计划生育专科医院人类精子库出于"生殖保险"目的的自精保存状况。方法对2003年6月至2016年6月期间出于"生殖保险"目的进行自精保存者行回顾性分析,内容包括生殖保险人数和原因、冷冻前后精液参数、自精保存者年龄、临床应用。根据生殖保险目的不同分为以备将来生育组;肿瘤放、化疗前组;夫妻两地分居组;绝育手术前组;乙型肝炎等疾病药物治疗前组。结果 13年间,共有347人出于"生殖保险"目的进行自精保存,年龄14~55(28.4±6.93)岁,自精保存者人数呈现逐年增长的趋势。自精保存者中放、化疗前肿瘤患者占82.99%,共有288人。复苏后均见活动精子,活动精子总数能满足辅助生殖技术要求。进行自精保存的人群大多数年龄集中于20~40岁的生育年龄段。共有15名自精保存者使用了冻存精液实施辅助生殖治疗,6人仅采用夫精人工授精(AIH),3人采用AIH+体外受精-胚胎移植术(IVF-ET),6人直接采用IVFET。其中AIH临床妊娠2人(2/6),IVF-ET临床妊娠4人(4/6),共有6人成功妊娠(6/15)。13年间共有3名自精保存者放弃存精,销毁了冻存精液。结论出于"生殖保险"目的进行自精保存者以肿瘤放、化疗前患者为主,其中又以睾丸肿瘤及淋巴瘤患者居多。"生殖保险"能有效保存男性生育力,也能获得比较满意的临床妊娠结局,对男性肿瘤患者进行治疗前"生殖保险"宣传,将更有利于放、化疗前患者生育力的保存。
[Abstract]:Objective to analyze the status of human sperm bank fine save from Guangzhou Family Planning Specialty Hospital for "reproductive insurance" purpose. Methods during the period from June 2003 to June 2016 for "reproductive insurance" to make a fine save from a retrospective analysis, including reproductive insurance and the number of reasons, the semen parameters before and after freezing, a fine save from age, reproductive according to clinical application. The purpose of insurance is divided into different group for future growth; radiotherapy, chemotherapy group; the couple separated group; sterilization group; drug hepatitis B disease before treatment group. Results in the past 13 years, a total of 347 people were out of a fine save from "reproductive insurance", the age of 14~55 (28.4 + 6.93) years old a fine save from the number, showed an increasing trend year by year. A fine save from who, before chemotherapy tumor patients accounted for 82.99%, a total of 288 people. The recovery activities were seen after sperm, sperm parameters can meet the auxiliary Requirements of reproductive technology help. Since the fine save most patients were focused on the age of childbearing age 20~40 years old. A total of 15 fine saves the use of cryopreserved semen to implement assisted reproductive treatment, only 6 with intrauterine insemination (AIH), 3 people with AIH+ in vitro fertilization and embryo transplantation (IVF-ET), 6 with IVFET. AIH 2 clinical pregnancy (2/6), 4 IVF-ET clinical pregnancy (4/6), a total of 6 successful pregnancy (6/15) during.13, a total of 3 fine saves to keep refined, the destruction of frozen semen. The conclusion for the "reproductive insurance" objective fine saves to cancer patients before chemotherapy, and the patients with testicular cancer and lymphoma. The majority of "reproductive insurance" can effectively preserve male fertility, can obtain satisfactory clinical outcome of pregnancy, the male cancer patients before treatment of "reproductive insurance" propaganda, will be more conducive to the release of chemotherapy The preservation of the fertility of the former patient.

【作者单位】： 广东省计划生育科学技术研究所男性科、广东省计划生育专科医院人类精子库;
【基金】：广东省医学科学技术研究基金资助(指令性课题)(编号:C2015016) 广东省公益研究与能力建设专项资金项目(编号:2014A070705011)
【分类号】：R714.8
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本文编号：1746984