补肾调冲祛瘀方联合HCG和黄体酮对抗心磷脂抗体阳性致早期复发性流产患者的干预效果

发布时间：2018-04-15 04:28

本文选题：补肾调冲祛瘀方 + 人绒毛膜促性腺激素　；参考：《河南中医学院》2014年硕士论文

【摘要】：目的：观察补肾调冲祛瘀方联合人绒毛膜促性腺激素(human chorionicgonadotropin，HCG)和黄体酮对肾虚血瘀型抗心磷脂抗体(anti cardiolipin antibody，ACA)阳性所致早期复发性流产(recurrent spontaneous abortion，RSA)患者在中医症候、ACA转阴率、保胎成功率、血清人绒毛膜促性腺激素(serum human chorionic gonadotropin，β-HCG)及孕酮(Progesterone，P)水平方面的影响；探讨补肾调冲祛瘀方联合HCG和黄体酮对肾虚血瘀型ACA阳性所致早期RSA的作用机理，为补肾调冲祛瘀方联合HCG和黄体酮治疗肾虚血瘀型ACA阳性所致早期RSA提供客观详实的依据。方法：按照整群抽样的方法，收集2012.10~2013.12期间就诊于河南中医学院第一附属医院妇产科门诊及住院部的ACA阳性所致早期RSA患者50例。分为两组：治疗组30例，以补肾调冲祛瘀方联合HCG和黄体酮治疗；对照组20例，以HCG和黄体酮治疗。评定两组患者治疗前后中医证候积分、血清β-HCG及P的变化情况；检测用药后ACA转阴率、保胎成功率的情况。结果：治疗组治疗前后中医证候积分经检验，差异有统计学意义(P＜0.05)，对照组治疗前后差异有统计学意义(P＜0.05)，两组治疗前后差值经检验差异有统计学意义(P＜0.05)。治疗后患者疗效指数分布情况治疗组较对照组差异有统计学意义(P＜0.05)。治疗组ACA转阴26人，有效率86.7%；对照组ACA转阴12人，有效率60.0%，差异有统计学意义(P＜0.05)。治疗组保胎成功26人，有效率86.7%；对照组保胎成功11人，有效率55.0%，差异有统计学意义（P＜0.05）。治疗组治疗前后血清β-HCG及P，，差异有统计学意义(P＜0.05)，对照组治疗前后差异有统计学意义(P＜0.05)。两组治疗前后差值经检验差异无统计学意义(P＞0.05)。结论：①补肾调冲祛瘀方联合HCG和黄体酮对ACA阳性所致早期RSA患者具有较好的干预效果,能改善患者的肾虚血瘀证侯，提高ACA转阴率、增加保胎成功率；②补肾调冲祛瘀方联合HCG和黄体酮能改善患者血清β-HCG及P水平。
[Abstract]:Objective: to observe the effect of Bushen Tiaochong Quyu recipe combined with human chorionic gonadotropin (HCG) and progesterone on early recurrent abortion induced by anti-cardiolipid antibody anti anti cardiolipin antibody-ACAA positive in patients with kidney deficiency and blood stasis syndrome.The effect of serum human chorionic gonadotropin (尾 -HCG) and progesterone Progesteroneone (P) on serum levels of serum human chorionic gonadotropin (尾 -HCG), to explore the mechanism of Bushen Tiaochong Quyu decoction combined with HCG and progesterone on early RSA induced by ACA positive of kidney deficiency and blood stasis type.It provides an objective and detailed basis for the treatment of early RSA caused by ACA positive of kidney deficiency and blood stasis type by Bushen Tiaochong Quyu recipe combined with HCG and progesterone.Methods: according to the method of cluster sampling, 50 patients with early RSA caused by ACA positive in gynecology and obstetrics department of the first affiliated Hospital of Henan College of traditional Chinese Medicine were collected from February 10 to December 2012.30 cases in the treatment group were treated with Bushen Tiaochong Quyu decoction combined with HCG and progesterone, and 20 cases in the control group were treated with HCG and progesterone.The changes of TCM syndromes, serum 尾 -HCG and P were evaluated before and after treatment, the conversion rate of ACA and the success rate of fetal preservation were detected.Results: the scores of TCM syndromes before and after treatment in the treatment group were significantly different (P < 0.05), the difference in the control group was significant (P < 0.05), and the difference between the two groups before and after treatment was statistically significant (P < 0.05).The distribution of curative effect index in the treatment group was significantly higher than that in the control group (P < 0.05).In the treatment group, 26 cases of ACA turned negative, the effective rate was 86.7%, while in the control group, ACA turned to negative in 12 cases, the effective rate was 60.0, the difference was statistically significant (P < 0.05).In the treatment group, 26 cases were successfully preserved and the effective rate was 86.7%, while in the control group, 11 cases were successfully preserved, the effective rate was 55.0%, the difference was statistically significant (P < 0.05).The difference of serum 尾 -HCG and Pin before and after treatment in the treatment group was statistically significant (P < 0.05), while that in the control group was significant (P < 0.05).There was no significant difference between the two groups before and after treatment (P > 0.05).Conclusion Bushen Tiaochong Quyu decoction combined with HCG and progesterone has better intervention effect on early RSA patients caused by positive ACA. It can improve the kidney deficiency and blood stasis syndrome, increase the negative rate of ACA, and increase the success rate of fetal preservation.2Bushen Tiaochong Quyu decoction combined with HCG and progesterone could improve serum 尾 -HCG and P levels.
【学位授予单位】：河南中医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.21

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