夫精宫腔内人工授精手术时机和妊娠相关性分析

发布时间：2018-04-15 07:05

本文选题：授精 + 人工　；参考：《国际生殖健康/计划生育杂志》2016年06期

【摘要】：目的:探讨夫精宫腔内人工授精(IUI)时机及次数与妊娠率的关系。方法:回顾性分析851对在广州医科大学附属第三医院行夫精IUI治疗的不孕夫妇(共1 751个周期),根据手术时机及次数,分为排卵前1次IUI、排卵后1次IUI、排卵前2次IUI、排卵前后各1次IUI 4组,比较4组妊娠率的差异。结果:排卵前、后行单次IUI组的妊娠率分别为11.21%和12.23%;排卵前行单次IUI后有排卵组妊娠率显著高于无排卵组(P0.05)。排卵前后各行1次IUI、排卵前行2次IUI妊娠率分别为16.21%和15.65%;排卵前行2次IUI后有排卵组临床妊娠率(17.14%)高于无排卵组(0.00%),差异有统计学意义(确切概率法P=0.040)。有排卵周期中,排卵前1次、排卵后1次、排卵前2次、排卵前后各1次IUI的临床妊娠率分别为10.99%、12.23%、17.14%、16.21%,行2次IUI组的妊娠率虽然高于行1次IUI组,但差异无统计学意义(P0.05)。结论:只要确定卵泡破裂,排卵前后行IUI、行1次或2次IUI妊娠率无差异;但IUI后卵泡无破裂,则妊娠率为0~2.85%,因此针对2个周期IUI出现未破裂卵泡黄素化综合征者建议转行体外受精。
[Abstract]:Objective: to investigate the relationship between intrauterine intrauterine insemination (IUI) and pregnancy rate.Methods: a total of 851 infertile couples (1 751 cycles) treated with IUI in the third affiliated Hospital of Guangzhou Medical University were analyzed retrospectively.They were divided into four groups: one time before ovulation, one time after ovulation, two times before ovulation, and one time before and after ovulation.Results: the pregnancy rates of single IUI group were 11.21% and 12.23% respectively before ovulation, and the pregnancy rate of single IUI group before ovulation was significantly higher than that of non-ovulation group (P 0.05).The pregnancy rates of IUI before and after ovulation were 16.21% and 15.65, respectively, and the clinical pregnancy rate was 17.14% in the group with IUI before ovulation 2 times before ovulation, which was significantly higher than that in the group without ovulation (P < 0.040).In the ovulatory cycle, the clinical pregnancy rate of IUI before and after ovulation was 10.99 and 12.23and 17.14, respectively. The pregnancy rate in the second IUI group was higher than that in the first IUI group, but the difference was not statistically significant (P 0.05).Conclusion: as long as follicular rupture is determined, there is no difference in pregnancy rate between once or twice IUI before and after ovulation, but there is no rupture of follicle after IUI.The pregnancy rate is 0 and 2.85, so it is recommended that IVF be converted to IVF for those with unruptured follicular luteinization syndrome in 2 cycles of IUI.
【作者单位】：广州医科大学附属第三医院生殖医学中心广东省生殖医学重点实验室;
【分类号】：R714.8

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