卵巢交界性肿瘤保守手术术后复发危险因素的Meta分析

发布时间：2018-04-15 08:20

  本文选题：卵巢交界性肿瘤 + 保守　； 参考：《兰州大学》2017年硕士论文

【摘要】：目的:系统评价卵巢交界性肿瘤(Borderline Ovarian Tumors,BOTs)保守手术术后复发的危险因素,为临床治疗和随访提供依据。方法:计算机检索PubMed、EMbase、The Cochrane Library(2016年第12期)、Web of Science、CNKI、CBM、WanFang Data、VIP等数据库,搜集所有研究卵巢交界性肿瘤保守手术术后复发危险因素的队列研究或病例对照研究,检索时限均从建库至2016年12月31日,同时手工检索相关国内期刊杂志,由2位研究员按照纳入、排除标准独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan5.3软件进行Meta分析。结果:全文最终纳入20个队列研究,共1064例患者。Meta分析结果显示:在术后复发率方面,FIGO≥Ⅱ期和FIGOⅠ期[OR=3.32,95%CI(1.56,7.05),P=0.002]、双侧卵巢肿瘤和单侧卵巢肿瘤[OR=3.51,95%CI(1.73,7.10),P=0.0005]、卵巢囊肿切除术和单侧附件切除术[OR=2.88,95%CI(1.82,4.56),P0.00001]、肿瘤包膜破裂和肿瘤包膜未破裂[OR=8.93,95%CI(2.73,29.20),P=0.0003]、交界性浆液性卵巢肿瘤(Serous Borderline Ovarian Tumors,SBOT)和交界性黏液性卵巢肿瘤(Mucinous Borderline Ovarian Tumors,MBOT)[OR=2.21,95%CI(1.49,3.28),P0.0001]、微乳头浸润和无微乳头浸润[OR=2.36,95%CI(1.32,4.24),P=0.004]的术后复发率差异有统计学意义,而FIGOⅠC期和FIGO≤ⅠB期[OR=1.32,95%CI(0.74,2.33),P=0.34]、术前CA125升高和术前CA125正常[OR=1.37,95%CI(0.53,3.53),P=0.51]、腹腔镜手术和开腹手术[OR=1.27,95%CI(0.88,1.85),P=0.20]、分期手术和未分期手术[OR=0.38,95%CI(0.11,1.26),P=0.11]、清扫淋巴结和未清扫淋巴结[OR=1.21,95%CI(0.34,4.30),P=0.77]、微浸润和无微浸润[OR=1.25,95%CI(0.69,2.25),P=0.46]、术后化疗和术后未化疗[OR=1.12,95%CI(0.43,2.90),P=0.81]对术后复发率的影响无统计学差异。结论:FIGO≥Ⅱ期、双侧卵巢肿瘤、卵巢囊肿切除术、肿瘤包膜破裂、SBOT、微乳头浸润是卵巢交界性肿瘤保守手术术后复发的危险因素。
[Abstract]:Objective: to evaluate the risk factors for recurrence of borderline Ovarian tumors after conservative surgery, and to provide evidence for clinical treatment and follow-up.Methods: a computer-based search of the Cochrane Library (issue 12 of 2016) was conducted to collect all cohort studies or case-control studies on the risk factors of recurrence of ovarian borderline tumors after conservative surgery.The time limit for retrieval was from the establishment of the database to December 31, 2016, and the relevant domestic periodical magazines were manually searched, which were included by two researchers, excluding the criteria for independent screening of literature, extracting data and evaluating the bias risks involved in the study.Meta analysis was carried out with RevMan5.3 software.Results: the full text was included in 20 cohort studies.鑰孎IGO鈪燙鏈熷拰FIGO鈮も厾B鏈焄OR=1.32,95%CI(0.74,2.33),P=0.34],鏈�鍓岰A125鍗囬珮鍜屾湳鍓岰A125姝ｅ父[OR=1.37,95%CI(0.53,3.53),P=0.51],鑵硅厰闀滄墜鏈�鍜屽迹�

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