盆腔器官脱垂与COL3A1基因多态性的Meta分析

发布时间：2018-04-15 14:37

本文选题：盆腔器官脱垂 + 基因多态性　；参考：《河南科技大学》2017年硕士论文

【摘要】：背景和目的:近年来,盆腔器官脱垂的发病率有所升高,严重影响着患者的工作和生活,且生活质量明显下降。盆腔器官脱垂的病因不明,众多学者认为和分娩、家族、肥胖等有关。基因多态性的研究为疾病的发生发展揭开了神秘的面纱。近年来有不少学者研究盆腔器官脱垂与COL3A1基因多态性之间的相关性,但是他们的研究结论存在分歧。本文旨在通过Meta分析探讨COL3A1的基因多态性与盆腔器官脱垂的发病易感性是否具有相关性,以及进一步探讨该基因的多态性是否增加盆腔器官脱垂的发病风险,以期为盆腔器官脱垂的病因学提供一定的循证医学证据。方法:通过对Pubmed、Medline、Embase、Cochrane、CNKI、万方数据库检索从建库至2016年10月的相关文献,提取数据,利用Review Manager 5.2软件对合并后的数据进行Meta分析,从而探讨COL3A1基因多态性和盆腔器官脱垂发生易感性的相关性。结果:研究共纳入5篇文章,其中包括1274名参与者(701名病例和573名对照)。等位基因A vs G:OR=0.98,95%CI 0.67-1.43,P=0.92;纯合子模型AA vs GG:OR=1.51,95%CI 0.47-4.82,P=0.48;杂合子模型GA vs GG:OR=0.89,95%CI 0.69-0.14,P=0.37;显性模型GA+AA vs GG:OR=0.92,95%CI 0.63-1.33,P=0.65;隐性模型AA vs GA+AA:OR=1.64,95%CI 0.54-4.95,P=0.38。结论:通过分析本研究的数据所得的森林图可知,COL3A1基因的多态性与盆腔器官脱垂的发病易感性无明显相关性,但是由亚组分析可知,盆腔器官脱垂的发生可能和种族有关。
[Abstract]:Background and objective: in recent years, the incidence of pelvic organ prolapse has increased, which seriously affected the work and life of patients, and the quality of life decreased significantly.The etiology of pelvic organ prolapse is unknown, and many scholars believe that it is related to childbirth, family, obesity and so on.The study of genetic polymorphisms has revealed the mystery of the occurrence and development of disease.In recent years, many researchers have studied the association between pelvic organ prolapse and COL3A1 gene polymorphism, but their conclusions are different.The aim of this study was to investigate the association between COL3A1 gene polymorphism and the susceptibility to pelvic organ prolapse by Meta analysis, and to further explore whether the polymorphism of the gene increased the risk of pelvic organ prolapse.In order to provide evidence-based medical evidence for the etiology of pelvic organ prolapse.Methods: through the retrieval of relevant documents from the establishment of the database to October 2016, the Review Manager 5.2 software was used to analyze the combined data by using Review Manager 5.2 software.To investigate the association between COL3A1 gene polymorphism and susceptibility to pelvic organ prolapse.Results: the study included 5 articles, including 1274 participants with 701 cases and 573 controls.Allele A vs GGO: 0.9895 CI 0.67-1.43P0.92; homozygous AA vs GGOR1.5195 95 CI 0.47-4.82 P0.48; heterozygote model GA vs GG: OR0.8995 CI 0.69-0.14P0.37; dominant model GA vs GGOR0.995 CI 0.63-1.33P0.65; recessive model AA vs GA > 1.6495CI 0.54-4.95P0. 38.Conclusion: there is no significant correlation between the polymorphism of COL3A1 gene and the susceptibility of pelvic organ prolapse, but the subgroup analysis shows that the occurrence of pelvic organ prolapse may be related to race.
【学位授予单位】：河南科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.2

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