宫颈癌术后限定骨盆骨髓剂量调强放疗的剂量学

发布时间：2018-04-16 06:19

本文选题：宫颈癌 + 调强放疗　；参考：《中国老年学杂志》2017年01期

【摘要】：目的探讨宫颈癌术后调强放疗中,限定与非限定骨盆骨髓剂量在靶区剂量学及危及器官保护的差异。方法 8例宫颈癌术后放疗患者分别根据靶区勾画要求勾画临床靶区(CTV)及危及器官,观察组在放疗计划设计时按要求限制骨盆骨髓受照剂量和体积;对照组不予以限制骨盆骨髓受照剂量和体积,并对此8例患者进行自身剂量学比较。结果 BMS-IMRT分别减少了对骨盆10 Gy、20 Gy、30 Gy、40 Gy剂量的照射体积,具有统计学意义(P0.05)。BMS-IMRT和IMRT两种治疗计划中肿瘤靶区覆盖率、膀胱V40、V50及直肠V40、V50、Dmean的值均相近(P0.05)。结论与IMRT相比,BMS-IMRT减少了对骨盆的照射剂量,且不增加肿瘤靶区覆盖率及直肠、膀胱等危及器官的照射剂量。
[Abstract]:Objective to investigate the difference between limited and unlimited pelvic bone marrow doses in target area and organ protection in postoperative intensity-modulated radiotherapy for cervical cancer.Methods eight patients with postoperative radiotherapy for cervical cancer were divided into two groups: according to the requirements of target area, CTV (clinical target area) and the organs at risk were delineated. The radiation dose and volume of bone marrow in the observation group were limited according to the requirements when the radiotherapy plan was designed.The control group did not limit the irradiation dose and volume of pelvis bone marrow.Results BMS-IMRT reduced the irradiation volume of 10 Gy / 20 Gy / 30 Gy / 40 Gy of pelvis respectively. There was significant difference in the coverage of tumor target area between the two treatment plans (P0.05N. BMS-IMRT and IMRT). The values of V40 V50 in bladder and V50 Dmean in rectum were close to P0.05.Conclusion compared with IMRT, BMS-IMRT can reduce the irradiation dose to pelvis, and does not increase the coverage of tumor target and the dose of dangerous organs such as rectum and bladder.
【作者单位】：吉林大学第二医院肿瘤中心放疗科;吉林大学生命科学学院;吉林大学基础医学院;
【基金】：国家自然科学基金资助(81320108)
【分类号】：R737.33;R730.55

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