康妇炎胶囊联合抗生素治疗盆腔炎性疾病随机对照研究

发布时间：2018-04-17 22:25

本文选题：康妇炎胶囊 + 盆腔炎性疾病　；参考：《中国实用妇科与产科杂志》2017年07期

【摘要】：目的评价康妇炎胶囊联合抗生素治疗盆腔炎性疾病的有效性及安全性。方法 2014年6月至2016年6月在复旦大学附属妇产科医院门诊募集盆腔炎性疾病(pelvic inflammation disease,PID)患者,随机分为研究组(康妇炎联合抗生素治疗)、对照组(抗生素治疗),分别在治疗前及治疗开始后第3天、第4周、第8周和12周进行PID症状、体征量化评分;在治疗前及治疗开始后第4周、12周超声测盆腔积液情况。在治疗前与治疗后第12周进行血常规、血生化、心电图、不良反应等安全性评估。结果两组患者PID症状量化评分明显下降,从治疗第3天开始研究组的PID量化评分显著低于对照组,直到治疗后第12周。研究组在治疗第12周左附件触痛显著好于对照组,治疗第8周、12周子宫触痛显著好于对照组。研究组在治疗第4、12周盆腔积液显著少于对照组。研究组在治疗第4、8、12周疗效显著优于对照组。研究组在治疗第12周复发率显著低于对照组。两组治疗前后安全性评价差异均无统计学意义。结论康妇炎胶囊联合抗生素能显著改善PID症状,降低复发,减少盆腔积液,使用安全,确切机制有待深入探讨。
[Abstract]:Objective to evaluate the efficacy and safety of Kangfuyan capsule combined with antibiotics in the treatment of pelvic inflammatory diseases.Methods from June 2014 to June 2016, patients with pelvic inflammatory inflammation disease were recruited from outpatient clinic of Obstetrics and Gynecology Hospital affiliated to Fudan University.They were randomly divided into study group (Kangfuyan combined with antibiotic therapy) and control group (antibiotic therapy group). Before and after treatment, PID symptoms and signs were quantified at 3 days, 4 weeks, 8 weeks and 12 weeks, respectively.Pelvic effusion was measured by ultrasonography before treatment and 4 weeks after treatment.The safety of blood routine, blood biochemistry, electrocardiogram and adverse reactions were evaluated before and 12 weeks after treatment.Results the quantitative scores of PID symptoms in the two groups were significantly lower than those in the control group from the 3rd day of treatment until the 12th week after treatment.The left appendage tenderness in the study group was significantly better than that in the control group at the 12th week and the uterine tenderness at the 8th week was significantly better than that in the control group.The pelvic effusion in the study group was significantly lower than that in the control group at the 4th week.The therapeutic effect of the study group was significantly better than that of the control group at the 4th week.The recurrence rate in the study group was significantly lower than that in the control group at week 12.There was no significant difference in safety evaluation between the two groups before and after treatment.Conclusion Kangfuyan capsule combined with antibiotics can significantly improve the symptoms of PID, reduce recurrence, reduce pelvic effusion, and use safely.
【作者单位】：复旦大学附属妇产科医院宫颈疾病诊疗中心上海市生殖内分泌重点实验室;
【分类号】：R711.33

【相似文献】