子宫内膜癌患者血清睾酮水平变化及意义

发布时间：2018-04-17 22:15

本文选题：子宫内膜癌 + 雄激素　；参考：《山东医药》2015年18期

【摘要】：目的探讨子宫内膜癌患者外周静脉血及卵巢静脉血中的睾酮水平与临床病理特征的关系。方法选择30例正常子宫内膜患者(对照组)及40例子宫内膜癌患者(观察组),采集两组外周静脉血和卵巢静脉血,用化学发光法检测血清睾酮水平。结果观察组外周静脉血睾酮水平高于对照组(P0.05);卵巢静脉血睾酮水平亦高于对照组,但差异无统计学意义。观察组睾酮随肿瘤FIGO分期升高、肌层浸润深度增加而降低(P均0.05),与肿瘤分化程度、淋巴结转移、腹腔积液或腹腔冲洗液细胞学结果无明显相关性(P均0.05)。两组卵巢静脉血睾酮水平均较外周静脉血增高(P均0.05)。结论子宫内膜癌患者的外周及卵巢静脉血中睾酮均升高,且与肿瘤FIGO分期、肌层浸润深度有关。监测血清睾酮水平有助于预测子宫内膜癌病情及指导其治疗。
[Abstract]:Objective to investigate the relationship between serum testosterone levels and clinicopathological features in patients with endometrial carcinoma.Methods 30 cases of normal endometrium (control group) and 40 cases of endometrial carcinoma (observation group) were selected. The peripheral venous blood and ovarian venous blood were collected and the serum testosterone levels were detected by chemiluminescence method.Results the serum testosterone level in the observation group was higher than that in the control group (P 0.05), and the serum testosterone level in the ovarian vein was higher than that in the control group, but the difference was not statistically significant.In the observation group, the levels of testosterone decreased with the increase of FIGO stage and the depth of myometrial infiltration (P < 0.05). There was no significant correlation between testosterone and tumor differentiation, lymph node metastasis, peritoneal effusion or peritoneal lavage fluid cytology.The serum testosterone level in both groups was higher than that in peripheral venous blood (P < 0.05).Conclusion testosterone levels in peripheral and ovarian veins of patients with endometrial carcinoma are increased, which is related to tumor FIGO stage and depth of myometrial invasion.Monitoring serum testosterone levels can help predict the state of endometrial carcinoma and guide its treatment.
【作者单位】：徐州医学院研究生院;徐州医学院附属连云港医院;
【分类号】：R737.33

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