降调节与非降调节激素替代内膜准备对冻融胚胎移植结局的影响

发布时间：2018-04-18 01:35

本文选题：冻融胚胎移植 + 垂体降调节　；参考：《现代妇产科进展》2015年06期

【摘要】：目的:比较3.75mg GnRHa降调节激素替代内膜准备方案与单纯激素替代内膜准备方案对冻融胚胎移植(FET)妊娠率的影响。方法:选取1225例(周期)行冻融胚胎移植患者,根据内膜准备方式分为激素替代周期组(A组)417例和降调节激素替代组808(B组)例。比较两组患者的种植率、妊娠率、流产率和生殖激素水平。结果:激素替代周期组和降调节激素替代组患者的种植率分别为33.6%和38.1%,临床妊娠率分别为52.3%和58.8%;两组的种植率和临床妊娠率比较差异均有统计学意义(P0.05)。降调节激素替代组的黄体酮注射日、ET前1日和ET后第3日LH低于A组,差异有统计学意义(P0.05)。两组患者的流产率和异位妊娠率比较,差异无统计学意义(P0.05)。结论:与传统激素替代内膜准备方案比较,3.75mg GnRHa降调节激素替代内膜准备方式可提高冻融胚胎移植妊娠率而不增加流产率。
[Abstract]:Aim: to compare the effects of 3.75mg GnRHa down-regulation hormone replacement endometrium preparation regimen and hormone replacement endometrium preparation regimen on pregnancy rate of frozen and thawed embryo transfer.Methods: 1225 cases of frozen and thawed embryo transfer were selected and divided into two groups according to the preparation of endometrium: group A (n = 417) and group B (n = 808).The implantation rate, pregnancy rate, abortion rate and reproductive hormone level were compared between the two groups.Results: the implantation rate was 33.6% and 38.1%, and the clinical pregnancy rate was 52.3% and 58.8% in the hormone replacement cycle group and the descending regulation hormone replacement group, respectively, and there was significant difference between the two groups in the implantation rate and the clinical pregnancy rate.The LH of the hyporegulation hormone replacement group was lower than that of group A on the day of progesterone injection and on the 3rd day after et, and the difference was statistically significant (P 0.05).There was no significant difference in abortion rate and ectopic pregnancy rate between the two groups (P 0.05).Conclusion: compared with the traditional hormone replacement endometrial preparation regimen, 3.75mg GnRHa down-regulation hormone replacement endometrial preparation can improve the pregnancy rate of frozen-thawed embryo transfer, but not the abortion rate.
【作者单位】：湖北医药学院附属人民医院生殖医学中心;
【分类号】：R714.8

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