益肾宁坤方治疗子宫内膜异位症术后加用GnRH-a所致围绝经期症状的临床研究

发布时间：2018-04-20 07:40

本文选题：益肾宁坤方 + 中药　；参考：《南京中医药大学》2014年硕士论文

【摘要】：目的：观察益肾宁坤方对子宫内膜异位症术后加用GnRH-a所致肝肾阴虚型围绝经期症状的疗效并探讨其机理。方法：所有患者为腹腔镜下卵巢巧克力囊肿剥除术,术后加用醋酸亮丙瑞林药物治疗,共6针24周,使用12周后出现符合肝肾阴虚型围绝经期症状的病例共90例,按随机数字表法分成三组治疗12周,其中对照组30例,单用醋酸亮丙瑞林,反向添加组30例同时每日加用替勃龙片(1.25mg/d)反向添加,口服中药组30例同时每日口服中药益肾宁坤方。治疗后比较三组患者潮热出汗、失眠、易激动、疲乏、骨关节肌肉痛、性生活障碍各项症状的改良Kupperman评分,并检测血清雌二醇(estradiol, E2)、卵泡刺激素(follicle-stimulating hormone, FSH)水平。观察三组患者盆腔超声及血清CA125情况。结果：各项症状的评分比较,对照组和反向添加组、对照组和口服中药组,差异均有统计学意义(P0.05),反向添加组和口服中药组,差异均无统计学意义(P0.05)。血清E2、FSH水平的比较,对照组和反向添加组、对照组和口服中药组在统计学上有显著性差异(P0.05),反向添加组和口服中药组无显著性差异(P0.05)。三组复查均无复发病例。结论：内异症术后加用促性腺激素释放激素类似物(gonadotrophin-releasing hormone agonist, GnRH-a)时,口服中药益肾宁坤方,不仅不影响内异症的疗效,而且可以明显减轻GnRH-a所致的围绝经期症状。
[Abstract]:Objective: to observe the effect of Yishen Ningkun recipe on the peri-menopausal symptoms of liver-kidney yin deficiency syndrome induced by GnRH-a and its mechanism. Methods: all the patients were treated by laparoscopic excision of chocolate cyst of ovary and treated with Leuprorelin Acetate for 24 weeks. After 12 weeks of treatment, 90 cases were found to be in line with the peri-menopausal symptoms of liver-kidney yin deficiency type. Three groups were randomly divided into three groups: control group (n = 30), control group (n = 30), control group (n = 30), control group (n = 30), reverse admixture group (n = 30) and tibolone group (n = 30), respectively. 30 patients in the oral Chinese medicine group were treated with Yishen Ningkun prescription daily at the same time. After treatment, the modified Kupperman scores of the symptoms of hot tidal sweating, insomnia, agitation, fatigue, osteoarticular muscle pain and sexual disturbance were compared, and serum estradiol, E _ 2 and follicle-stimulating hormone follicle-stimulating hormone (FSHs) were measured. Pelvic ultrasound and serum CA125 were observed in three groups. Results: there were significant differences in the scores of each symptom between the control group and the reverse addition group, the control group and the oral Chinese medicine group, but there was no significant difference between the reverse addition group and the oral Chinese medicine group (P 0.05). The comparison of serum E2FSH levels showed that there were significant statistical differences between the control group and the reverse adding group, the control group and the oral Chinese medicine group (P 0.05), but there was no significant difference between the reverse addition group and the oral Chinese medicine group (P 0.05). There were no recurrence cases in all three groups. Conclusion: when the gonadotrophin-releasing hormone antagonist (GnRH-a) is added to the patients with endometriosis after operation, the oral administration of Yishen Ningkun prescription not only does not affect the curative effect of endometriosis, but also can obviously alleviate the peri-menopausal symptoms caused by GnRH-a.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R713.4

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