围产期生殖道感染病原菌构成与耐药性分析

发布时间：2018-04-20 17:16

本文选题：围产期 + 生殖道感染　；参考：《中华医院感染学杂志》2015年10期

【摘要】：目的探析围产期生殖道感染病原菌构成特点及其耐药性,为临床合理用药提供参考。方法收集医院2011年1月-2014年1月围产期生殖道感染患者送检标本2 040份,对标本进行病原学检测及药敏试验,统计感染病原菌分布及其耐药性;使用SPSS17.0软件进行统计分析。结果 2 040份送检标本中共检出病原菌90株,阳性检出率为4.4%,其中革兰阳性菌37株占41.1%,以金黄色葡萄球菌和链球菌属为主,革兰阴性菌53株占58.9%,以大肠埃希菌、肺炎克雷伯菌为主;24株金黄色葡萄球菌中MRSA检出6株,对青霉素耐药率最高,为70.8%,对阿米卡星、利福平、呋喃妥因、万古霉素高度敏感,耐药率5.0%,链球菌属对红霉素的耐药率最高,为88.9%,对美罗培南、克拉维酸/阿莫西林高度敏感,耐药率为0;53株革兰阴性菌对氨苄西林/舒巴坦耐药率最高,为30.2%,对亚胺培南的耐药率为0。结论对围产期生殖道感染患者予以病原学检测,了解其耐药趋势及病原菌构成,对降低围产期生殖道感染率、降低耐药菌株产生、合理选择抗菌药物、控制医源性流行及感染暴发具有重要的临床意义。
[Abstract]:Objective to explore the characteristics and drug resistance of pathogenic bacteria in perinatal genital tract infection, and to provide reference for rational use of drugs in clinic. Methods from January 2011 to January 2014, 20 040 specimens of perinatal genital tract infection were collected, and the pathogen distribution and drug resistance were analyzed by SPSS17.0 software. Results 90 strains of pathogenic bacteria were detected in 2 040 samples, and the positive rate was 4.4%. Among them, 37 strains of Gram-positive bacteria accounted for 41.1%, mainly Staphylococcus aureus and Streptococcus, 53 strains of Gram-negative bacteria accounted for 58.9%, and Escherichia coli was the main bacteria. Among 24 strains of Klebsiella pneumoniae, 6 strains of Staphylococcus aureus were detected by MRSA, with the highest resistance to penicillin (70.8%), highly sensitive to amikacin, rifampicin, furantoin and vancomycin. The resistance rate of Streptococcus to erythromycin was the highest (88.9), highly sensitive to meropenem, clavulanic acid / amoxicillin, and resistant to ampicillin / sulbactam among 53 Gram-negative strains. The resistance rate to imipenem was 0. 2%. Conclusion to detect the pathogen of perinatal genital tract infection, to understand the trend of drug resistance and the composition of pathogenic bacteria, to reduce the perinatal genital tract infection rate, to reduce the production of drug-resistant strains, and to select antibiotics reasonably. It is of great clinical significance to control iatrogenic epidemic and infection outbreak.
【作者单位】：聊城市东昌府人民医院;聊城市东昌府区妇幼保健院;
【基金】：山东省科技厅基金资助项目(JBS2013-3-26A-4)
【分类号】：R714.7

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