P16免疫组织化学检测评价高级别宫颈上皮内瘤变锥形切除后残留的临床价值

发布时间：2018-04-24 05:07

本文选题：P + 宫颈锥切　；参考：《重庆医学》2017年23期

【摘要】：目的探讨P16免疫组织化学检测联合常规病理评判高级别宫颈上皮内瘤变(CIN)锥形切除后切缘病灶残留的可行性。方法选择2014年1月至2016年5月到该院就诊的CIN行宫颈锤形切除的患者,根据患者的意愿分为P16免疫组织化学检测结合常规病理评价组和常规病理评价组评判切缘是否存在病灶残留。切缘残留的患者按照临床指南给予相应处理,在切缘无残留后6个月进行宫颈液基诱层细胞学(TCT)检测随访。以随访结果为金标准,分析两组灵敏度和准确率。结果 P16免疫组织化学检测结合常规病理评价组104例患者术后6个月TCT检查均为阴性,单纯常规病理评价组112例患者术后6个月TCT检查发现7例患者阳性。P16免疫组织化学检测结合常规病理评价组的灵敏度和准确率均达到100%,显著高于常规病理评价组。结论 P16免疫组织化学检测结合常规病理能够准确地判断高级别CIN锥形切除患者的切缘情况。
[Abstract]:Objective to investigate the feasibility of P16 immunohistochemistry combined with routine pathology in the evaluation of residual lesions at the incisal margin after conical resection of high grade cervical intraepithelial neoplasia (CINs). Methods from January 2014 to May 2016, patients with CIN undergoing cervical hammer resection were selected. According to the wishes of the patients, the patients were divided into two groups: P16 immunohistochemistry combined with routine pathological evaluation group and routine pathological evaluation group. The patients with residual margin were treated according to the clinical guidelines and followed up by TCTs at 6 months after no residue in the incisal margin. The sensitivity and accuracy of the two groups were analyzed according to the gold standard of follow-up results. Results P16 immunohistochemical examination combined with routine pathological evaluation group showed negative TCT in all 104 patients 6 months after operation. The sensitivity and accuracy of P16 immunohistochemistry combined with routine pathological evaluation group were 100, significantly higher than that of routine pathological evaluation group, which was significantly higher than that of routine pathological evaluation group. TCT examination showed that 7 cases were positive. P16 immunohistochemical assay combined with routine pathological evaluation group had a sensitivity and accuracy of 100%, significantly higher than that of routine pathological evaluation group. Conclusion P16 immunohistochemistry combined with routine pathology can accurately determine the incisal margin of patients with high grade CIN conical resection.
【作者单位】：广西壮族自治区柳州市妇幼保健院病理科;广西壮族自治区柳州市妇幼保健院检验科;
【基金】：柳州市科学研究与技术开发计划(2014J030418)
【分类号】：R737.33

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