宫颈癌患者化疗前后骨桥蛋白表达水平的变化及意义

发布时间：2018-04-25 03:15

本文选题：宫颈癌 + 骨桥蛋白　；参考：《广东医学》2015年10期

【摘要】：目的探讨宫颈癌化疗前后骨桥蛋白(OPN)含量变化,分析OPN表达对宫颈癌化疗效果的评价价值。方法选取80例接受化疗治疗的宫颈癌患者作为观察对象,对比患者接受化疗前后OPN含量及OPN阳性表达率差异。同时根据化疗结果将患者分为化疗无效组及化疗有效组两组,分别对比两组化疗前后OPN含量及OPN阳性表达率差异。对比化疗效果与治疗前后OPN含量差的相关性。结果患者化疗前OPN含量为(24.88±7.02)ng/m L,OPN阳性表达率为70.00%,明显高于化疗后的(19.77±7.17)ng/m L及41.25%(P0.05)。化疗无效组和化疗有效组化疗前的OPN含量及OPN阳性表达率分别为(24.61±7.06)ng/m L、69.39%及(25.15±6.36)ng/m L、70.97%,两组比较差异无统计学意义(P0.05),化疗后化疗有效组OPN含量及OPN阳性表达率为(17.16±7.12)ng/m L及35.48%,明显低于化疗无效组的(22.61±7.23)ng/m L及59.18%(P0.05)。化疗效果与治疗前后OPN含量差存在显著的正向直线相关关系(P0.05)。结论化疗后宫颈癌OPN含量及OPN阳性表达率均明显降低,且以化疗有效者降低更明显。
[Abstract]:Objective to investigate the changes of osteopontin (OPN) content in cervical cancer before and after chemotherapy, and to evaluate the value of OPN expression in the treatment of cervical cancer. Methods 80 cases of cervical cancer treated with chemotherapy were selected as observation objects. The OPN content and the positive rate of OPN expression were compared before and after chemotherapy. According to the results of chemotherapy, the patients were divided into two groups: the ineffective group and the effective group. The content of OPN and the positive expression rate of OPN were compared between the two groups before and after chemotherapy. The correlation between the effect of chemotherapy and the difference of OPN content before and after treatment was compared. Results the positive expression rate of OPN before chemotherapy was 24.88 卤7.02)ng/m, which was significantly higher than that after chemotherapy (19.77 卤7.17)ng/m L and 41.25% P 0.05). The OPN content and the positive expression rate of OPN were 24.61 卤7.06)ng/m LU 69.39% and 25.15 卤6.36)ng/m L 70.97in the ineffective group and the effective group before chemotherapy, respectively. There was no significant difference between the two groups (P 0.05). The OPN content and the positive rate of OPN expression in the effective group after chemotherapy were 17.16 卤7.12)ng/m L and 35.48%, respectively. It was significantly lower than that in the group without chemotherapy (22.61 卤7.23)ng/m / L) and in the group of 59.18 (P 0.05). There was a significant positive linear correlation between the effect of chemotherapy and the difference of OPN content before and after treatment (P 0.05). Conclusion the OPN content and the positive expression rate of OPN were significantly decreased in cervical cancer after chemotherapy, especially in the patients who were effective in chemotherapy.
【作者单位】：青海大学附属医院妇科;
【分类号】：R737.33

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