克罗米芬组合低剂量促性腺激素方案和常规拮抗剂方案在体外授精胚胎移植治疗中的临床治疗结局比较

发布时间：2018-04-26 14:46

本文选题：克罗米芬 + 促性腺激素　；参考：《南京医科大学学报(自然科学版)》2017年12期

【摘要】：目的 :比较卵巢功能正常的体外授精胚胎移植治疗患者,应用克罗米芬组合低剂量促性腺激素方案和常规拮抗剂方案的临床治疗结局。方法:应用前瞻性随机对照研究,选择2014年9月—2015年12月在南京医科大学第一附属医院就诊,女方卵巢功能评估正常,拟行体外授精胚胎移植治疗的120对夫妇为研究对象。按随机数字信封法分为实验组(克罗米芬组合低剂量促性腺激素方案)和对照组(常规拮抗剂方案)进行促排卵及体外授精胚胎移植治疗,两组均行全胚冷冻,择期冻融胚胎移植,随访至活产或用完本次取卵周期形成的所有胚胎,比较两组患者治疗的临床指标、实验室指标和临床妊娠结局。结果:实验组患者促性腺激素用量低于对照组、促性腺激素用药天数短于对照组,但两组患者临床妊娠率、活产率的差异无统计学意义。结论:克罗米芬组合低剂量促性腺激素方案,在促性腺激素用量减少和用药天数缩短情况下,能达到常规拮抗剂方案的临床治疗结局,是一种经济、有效、温和的新促排卵方案。
[Abstract]:Aim: to compare the clinical outcomes of low dose gonadotropin regimen and conventional antagonist regimen in patients undergoing IVF with normal ovarian function. Methods: a prospective randomized controlled study was carried out in 120 couples who attended the first affiliated Hospital of Nanjing Medical University from September 2014 to December 2015 and who had normal ovarian function evaluation and planned in vitro insemination embryo transfer therapy. According to the random digital envelope method, the experimental group (clomiphene combined with low dose gonadotropin regimen) and the control group (routine antagonist regimen) were divided into two groups: ovulation promotion and in vitro fertilization and embryo transfer. The clinical indexes, laboratory indexes and clinical pregnancy outcome of the two groups were compared. Results: the dosage of gonadotropin in the experimental group was lower than that in the control group, and the days of administration of gonadotropin was shorter than that of the control group, but there was no significant difference between the two groups in clinical pregnancy rate and live birth rate. Conclusion: the combination of clomiphene and low dose gonadotropin can achieve the clinical outcome of routine antagonist regimen under the condition of reducing the dosage of gonadotropin and shortening the days of administration of gonadotropin, which is economical and effective. A mild new ovulation promotion program.
【作者单位】：南京医科大学第一附属医院生殖医学中心生殖医学国家重点实验室;
【基金】：国家科技重大专项子课题(2017YFC1001300)
【分类号】：R714.8

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