Aurora-A和Survivin在子宫内膜癌中的表达及意义

发布时间：2018-04-26 17:55

本文选题：子宫内膜癌 + Aurora-A　；参考：《中国老年学杂志》2017年15期

【摘要】：目的检测子宫内膜癌中Aurora激酶(Aurora)-A和生存素(Survivin)的表达,关注二者表达的特征和相关性。方法 49例诊断为子宫内膜癌并行根治术的患者为观察组,留取术后蜡块组织,20例正常增生期子宫内膜组织为对照组。应用免疫组化SP法检测两组中Aurora-A和Survivin的表达。结果 Aurora-A和Survivin在两组中的表达差异有统计学意义(P0.01)。观察组中Aurora-A和Survivin的阳性率与肿瘤的最大径密切相关,Aurora-A的阳性率与脉管侵犯和肌层浸润密切相关,Survivin的阳性率与淋巴结转移密切相关。线性相关分析显示观察组中Aurora-A和Survivin无明显相关性。结论子宫内膜癌中Aurora-A和Survivin高表达可以促进病变的形成和发展。Aurora-A和Survivin无明显协同作用。
[Abstract]:Objective to detect the expression of Aurora kinase AuroraA and survivin in endometrial carcinoma, and to investigate their expression characteristics and correlation. Methods 49 cases of endometrial carcinoma were treated with radical resection and 20 cases of normal proliferative endometrium were taken as control group. Immunohistochemical SP method was used to detect the expression of Aurora-A and Survivin in the two groups. Results the expression of Aurora-A and Survivin was significantly different between the two groups (P 0.01). The positive rate of Aurora-A and Survivin was closely related to the maximum diameter of tumor. The positive rate of Aurora-A was closely related to vascular invasion and myometrium invasion. The positive rate of survivin was closely related to lymph node metastasis. Linear correlation analysis showed that there was no significant correlation between Aurora-A and Survivin in the observation group. Conclusion the high expression of Aurora-A and Survivin in endometrial carcinoma can promote the formation and development of endometrial carcinoma. Aurora-A and Survivin have no synergistic effect.
【作者单位】：郑州大学附属医院南阳医院(南阳市中心医院)妇产科;南阳医学高等专科学校临床医学系妇产科教研室;
【分类号】：R737.33

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