妊娠期糖尿病患者糖化血红蛋白水平与母婴结局的关系研究

发布时间：2018-04-29 17:35

本文选题：妊娠期糖尿病 + 糖化血红蛋白　；参考：《实用妇科内分泌杂志(电子版)》2016年08期

【摘要】：目的研究妊娠期糖尿病(GDM)糖化血红蛋白水平(HbA1c)与母婴结局的关系。方法选取2015年1月~2015年12月我院收治的GDM患者86例为观察组,同期选取正常孕妇86例为对照组。观察组控制血糖,并追踪至终止妊娠。观察两组孕妇的HbA1c水平、不良妊娠结局。结果两组孕妇第2次测定的HbA1c水平均低于第1次,差异有统计学意义(P0.05),且观察组孕妇2次HbA1c测定水平均显著高于对照组,差异有统计学意义(P0.05);观察组早产、羊水过多、巨大儿及宫内窘迫的发生率均显著高于对照组,差异有统计学意义(P0.05);HbA1c6.5%组的早产、羊水过多、巨大儿及宫内窘迫的发生率均显著高于≤6.5%组,差异有统计学意义(P0.05)。结论 GDM患者的HbA1c与不良妊娠结局发生率呈正相关,加强Hb A1c的测定,可预测妊娠结局,确保母婴安全。
[Abstract]:Objective to study the relationship between glycosylated hemoglobin (HbA1c) and maternal and infant outcomes in GDMs of gestational diabetes mellitus (GDM). Methods 86 patients with GDM from January 2015 to December 2015 were selected as observation group and 86 normal pregnant women as control group. The observation group controlled the blood sugar and followed up to the termination of pregnancy. HbA1c levels and adverse pregnancy outcomes were observed in both groups. Results the level of HbA1c in the second time was lower than that in the first, the difference was statistically significant (P 0.05), and the level of HbA1c in the observation group was significantly higher than that in the control group (P 0.05), the observation group was preterm delivery, the amniotic fluid was excessive, and the level of HbA1c in the observation group was significantly higher than that in the control group (P 0.05). The incidence of macrosomia and intrauterine distress was significantly higher than that of the control group. The difference was statistically significant in the preterm labor, amniotic fluid excess, macrosomia and intrauterine distress in the P0.05HbA1c6.5% group (P < 6.5%), and the difference was statistically significant (P 0.05). Conclusion there is a positive correlation between the incidence of adverse pregnancy outcome and HbA1c in patients with GDM. Strengthening the measurement of HB A1c can predict the pregnancy outcome and ensure the safety of mother and child.
【作者单位】：山东大学附属济南市中心医院保健科;济南军区总医院麻醉科;
【分类号】：R714.256

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