精子顶体精氨酸酰胺酶测定在体外受精-胚胎移植妊娠结局中的价值研究

发布时间：2018-04-30 09:39

  本文选题：精子 + 精氨酸酰胺酶　； 参考：《中华生殖与避孕杂志》2017年07期

【摘要】：目的研究精子顶体精氨酸酰胺酶在体外受精-胚胎移植(IVF-ET)中的应用价值。方法选择349个IVF治疗周期,其中精氨酸酰胺酶高值组162个周期,精氨酸酰胺酶低值组187个周期。比较两组间的受精率、正常受精率、卵裂率、优质胚胎率以及新鲜移植周期的生化妊娠率、临床妊娠率、流产率及活产率等指标。结果精子精氨酸酰胺酶高值组的受精率(78.74%)高于低值组(76.07%,P0.05),而卵裂率高值组(98.24%)低于低值组(99.58%,P0.05)。两组间正常受精率和优质胚胎率比较无统计学差异。高值组新鲜移植周期的临床妊娠率(58.75%)及活产率(52.50%)均明显高于低值组(44.00%,P0.05;33.00%,P0.01)。两组间生化妊娠率和流产率比较无统计学差异(P0.05)。结论精子精氨酸酰胺酶活性与IVF-ET精卵结合有一定关系,并对妊娠结局有一定的指导作用。
[Abstract]:Objective to study the application value of sperm acrosome arginine acylase in IVF-ETS. Methods A total of 349 IVF cycles were selected, including 162 cycles in the high value group and 187 cycles in the low value group. The fertilization rate, normal fertilization rate, cleavage rate, high quality embryo rate, biochemical pregnancy rate, clinical pregnancy rate, abortion rate and live delivery rate were compared between the two groups. Results the fertilization rate (78.74) in the high value group of arginase was higher than that in the low value group (76.07%), while the cleavage rate in the high value group (98.24%) was lower than that in the low value group (99.58%). There was no significant difference in normal fertilization rate and high quality embryo rate between the two groups. The clinical pregnancy rate (58.75) and live birth rate (52.50) in the high value group were significantly higher than those in the low value group (44.00%, P 0.05 and 33.00%, P 0.01). There was no significant difference in biochemical pregnancy rate and abortion rate between the two groups (P 0.05). Conclusion there is a certain relationship between sperm arginine acylase activity and IVF-ET spermatozoa binding, and it has a certain guiding effect on pregnancy outcome.
【作者单位】： 南京医科大学附属苏州市立医院生殖与遗传中心;
【基金】：江苏省遗传医学重点学科基金(FXK201305) 江苏省自然基金(BK2012601) 苏州市临床医学中心(SZZX201505) 江苏省医学创新团队(CXTDB2017013)~~
【分类号】：R714.8
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本文编号：1824039