主动免疫治疗原因不明复发性流产1005例疗效评价

发布时间：2018-05-02 16:24

  本文选题：原因不明复发性流产 + 主动免疫治疗　； 参考：《实用妇产科杂志》2016年04期

【摘要】：目的:评价原因不明复发性流产(URSA)主动免疫治疗的临床效果。方法:2001年2月至2015年2月在我院门诊就诊的URSA患者1005例为研究对象,取其丈夫或与女方无血缘关系的第三方男性的肘静脉血20 ml,分离淋巴细胞于孕前后注射于患者前臂,使其产生主动免疫,并随访妊娠结局。结果:1005例URSA患者中共妊娠894例(88.96%),其中足月分娩718例(71.44%),随访截止时,尚在妊娠中91例(9.05%),再次自然流产85例(8.46%);无早产病例;未受孕111例(11.04%)。年龄32岁者流产率明显高于≤32岁者(P0.05)。孕后免疫治疗2~3次者比孕后未治疗或仅治疗1次者的足月分娩率明显更高(P0.05),流产率明显更低(P0.05)。结论:主动免疫治疗URSA患者疗效肯定,妊娠成功率高,年龄大于32岁者妊娠后应早期保胎治疗;免疫治疗后3个月内受孕,确认早孕后再免疫治疗2~3次效果更好。
[Abstract]:Objective: to evaluate the clinical effect of active immunotherapy for unexplained recurrent abortion. Methods: from February 2001 to February 2015, 1005 URSA patients in our outpatient clinic were studied. The blood samples of the elbow vein of their husband or the third party male who had no blood relationship with the woman were collected and injected into the patient's forearm before pregnancy. Active immunity was produced and pregnancy outcome was followed up. Results A total of 894 pregnancies were found in 894 cases of URSA, including 718 cases of full-term delivery. At the end of follow-up, 91 cases were still in pregnancy, 85 cases had spontaneous abortion, 85 cases had spontaneous abortion, no cases were premature, and 111 cases were not pregnant. The abortion rate of 32 years old was significantly higher than that of 鈮，

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