妊娠早中期服用阿司匹林对子痫前期高危人群预防作用的系统性评价

发布时间：2018-05-02 18:08

本文选题：阿司匹林 + 子痫前期　；参考：《南方医科大学学报》2015年06期

【摘要】：目的系统性评价妊娠早中期服用阿司匹林对子痫前期高危人群的预防作用。方法全面检索Pub Med、Cochrane、OVID、web of science、Science Direct、EBSCO、Embase等英文数据库以及临床试验注册数据,纳入所有研究妊娠早中期服用阿司匹林对高危人群PE预防作用的相关文献,利用Revman 5.3软件对数据进行meta分析。结果最终纳入5个随机对照试验,860例受试者。结果显示,子痫前期高危人群妊娠16周前开始服用阿司匹林,妊娠期高血压发病风险(OR=0.35,95%CI 0.17-0.75,P=0.007)、子痫前期发病风险(OR=0.75,95%CI 0.47-0.98,P=0.04)、胎儿宫内生长受限发病风险(OR=0.53,95%CI 0.29-0.98,P=0.04)以及早产发病风险(OR=0.20,95%CI 0.08-0.48,P0.001)均较对照组降低,且试验组较对照组新生儿平均出生体质量增加了107.15 g,差异有统计学意义(95%CI 76.13-138.18,P0.001)。结论子痫前期高危人群妊娠16周前开始服用阿司匹林可降低妊娠期高血压、子痫前期发病风险、胎儿宫内生长受限、早产风险,提高新生儿出生体质量。
[Abstract]:Objective to evaluate the preventive effect of aspirin on high-risk population of preeclampsia. Methods the English database such as Pub Medsite Cochraneof Science Direct Science Embase and the registration data of clinical trials were searched, and all the literatures about the preventive effect of aspirin on PE in high risk population were included. Meta 5.3 software was used to analyze the data. Results 860 subjects were included in 5 randomized controlled trials. The results showed that people at high risk of preeclampsia began taking aspirin 16 weeks before pregnancy. The risk of hypertension complicating pregnancy 0.3595 CI 0.17-0.75P0. 007, preeclampsia 0.75 95 CI 0.47-0.98P0. 04, fetal growth restriction 0. 539 95 CI 0. 29-0.98P0.04) and preterm labor risk OR0.20 95 CI 0. 08-0.48P0.001) were lower than those of the control group. The average birth weight of the experimental group was 107.15 g higher than that of the control group, and the difference was statistically significant (P 0.001). Conclusion taking aspirin before 16 weeks of pregnancy in high risk group of preeclampsia can reduce the risk of hypertension during pregnancy, preeclampsia, fetal growth restriction and premature delivery, and improve the birth weight of newborns.
【作者单位】：南方医科大学南方医院妇产科;
【基金】：国家自然科学基金(81471464)~~
【分类号】：R714.244

【共引文献】