影响体外受精—胚胎移植临床妊娠结局的多因素分析

发布时间：2018-05-03 14:46

  本文选题：体外受精 + 胚胎移植　； 参考：《中国现代医药杂志》2016年12期

【摘要】：目的探讨影响体外受精—胚胎移植(IVF-ET)临床妊娠结局的相关因素。方法回顾性分析2013年1月~2015年12月于本中心行IVF/ICSI-ET治疗的鲜胚移植胚胎着床率为100%或0%的594例患者资料,比较(全胚着床)妊娠组与(零胚着床)非妊娠组的基本临床资料,采用二元Logistic回归模型分析可能影响妊娠结局的相关因素;分别比较不同年龄阶段和HCG日子宫内膜厚度的助孕结局。结果妊娠组和非妊娠组间年龄、不孕年限、HCG日子宫内膜厚度、Gn总量、优质胚胎数差异均有统计学意义(P0.05)。进入二元Logistic回归模型的相关因素为年龄(OR=-0.118,95%CI=0.845~0.935,P=0.000),优质胚胎数(OR=0.081,95%CI=1.016~1.156,P=0.014),HCG日子宫内膜厚度(OR=0.203,95%CI=1.088~1.380,P=0.001)。年龄≥38岁组临床妊娠率显著低于35岁各组(P0.05);HCG日子宫内膜厚度≥8mm各组临床妊娠率均显著高于内膜厚度8mm组(P0.05)。结论年龄及优质胚胎数、HCG日子宫内膜厚度为临床妊娠结局的独立影响因素。年龄≥38岁患者临床妊娠率显著降低。HCG日子宫内膜厚度≥8mm有助于提高临床妊娠率。
[Abstract]:Objective to investigate the related factors influencing the clinical pregnancy outcome of IVF-ETS in vitro fertilization-embryo transfer (IVF-et). Methods the data of 594 cases of fresh embryo implantation treated with IVF/ICSI-ET from January 2013 to December 2015 in our center were retrospectively analyzed. The clinical data of pregnant group (full embryo implantation) and non-pregnancy group (zero embryo implantation) were compared. A binary Logistic regression model was used to analyze the related factors that might influence the outcome of pregnancy and to compare the outcome of assisted pregnancy at different ages and on the day of HCG. Results there were significant differences in the total endometrial thickness and the number of high quality embryos between the gestational group and the non-pregnant group, as well as between the infertile years and the day of HCG. There were significant differences in the number of high quality embryos between the two groups (P 0.05). The relevant factors for entering the dual Logistic regression model were: age: 0.11895, CI0.845, 0.935, P0. 000, and the number of good quality embryos, 1. 01616, 1. 156, P0. 014, 0. 2039. 95 CI 1.088, 1. 380, P0. 001. The clinical pregnancy rate of age 鈮，

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