5-氨基酮戊酸光动力疗法联合卡介菌多糖核酸注射治疗宫颈HPV感染的疗效观察

发布时间：2018-05-06 00:06

本文选题：人乳头状瘤病毒 + 宫颈感染　；参考：《中国艾滋病性病》2015年01期

【摘要】：目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)联合卡介菌多糖核酸注射,治疗宫颈人乳头状瘤病毒(HPV)感染的疗效和安全性。方法 208例女性宫颈拭子聚合酶链反应(PCR)检测HPV 16、18高危型阳性的患者,采用数字随机法分为治疗组和对照组,每组各104例。治疗组外敷10%的5-氨基酮戊酸(ALA)于宫颈处,3小时后照光。每周1次,共3次。同时肌注卡介菌多糖核酸,隔日1次,连用3个月。对照组只给予肌注卡介菌多糖核酸,隔日1次,连用3个月。治疗结束后连续6个月每两个月进行一次宫颈拭子PCR-HPV检查,总结病毒清除有效率。结果治疗组病毒清除有效率达87.25%(89/102),对照组仅为71.84%(74/103),差异有显著统计学意义(P0.05)。治疗组患者照光局部有轻度红斑、肿胀、灼痛、未予治疗自行消退。结论 ALA-PDT联合卡介菌多糖核酸注射方法简单,高效,不良反应轻微,清除宫颈HPV感染明显优于对照组,能有效清除宫颈HPV隐患。
[Abstract]:Objective to investigate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with BCG polysaccharide nucleic acid injection in the treatment of cervical papillomavirus (HPV) infection. Methods 208 female cervical swabs were detected by polymerase chain reaction (PCR). The patients with high risk type HPV 16 ~ (18) were randomly divided into treatment group and control group with 104 cases in each group. In the treatment group, 10% 5-aminolevulinic acid (ALAA) was applied to the cervix for 3 hours. Once a week, three times a week. Meanwhile, BCG polysaccharide nucleic acid was injected intramuscularly once every other day for 3 months. The control group was given intramuscular injection of BCG polysaccharide nucleic acid once every other day for 3 months. After 6 months of treatment, cervical swab PCR-HPV was performed every two months to summarize the effective rate of virus clearance. Results the effective rate of virus clearance in the treatment group was 87.25% / 102%, while that in the control group was 71.84% / 103%. The difference was statistically significant (P 0.05). The patients in the treatment group had mild erythema, swelling and burning pain. Conclusion the injection of ALA-PDT combined with BCG-polysaccharide nucleic acid is simple, effective and mild. The removal of cervical HPV infection is better than that of the control group, and can effectively remove the hidden danger of HPV in the cervix.
【作者单位】：河北省衡水市哈励逊国际和平医院;衡水市第二人民医院急诊科;衡水市妇幼保健院;
【分类号】：R711.3

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