二甲双胍联合利格列汀治疗多囊卵巢综合征62例疗效观察

发布时间：2018-05-06 04:15

本文选题：多囊卵巢综合征 + 利格列汀　；参考：《山东医药》2015年33期

【摘要】：目的观察二甲双胍联合利格列汀治疗多囊卵巢综合征(PCOS)患者的疗效。方法将119例PCOS患者随机编入对照组57例和观察组62例,两组均给予二甲双胍治疗,起始剂量0.25 g/次,3次/d,耐受后增至0.5 g/次;观察组在此基础上加用利格列汀,5 mg/次,1次/d。6个月后比较两组体质量、空腹血糖(FPG)、餐后血糖(2h PG)、空腹胰岛素(FINS)、血脂(TC、TG、HDL-C、LDL-C)、内分泌激素(E2、T、FSH、LH)的变化,进行多毛评分,监测患者月经周期、排卵及妊娠情况。结果治疗6个月后,观察组BMI、FINS、HOMA-IR、TC、TG、2 h PG、HOMA-β、LH、LH/FSH、睾酮、多毛评分均显著低于对照组(P均0.01),HDL、FSH显著高于对照组(P均0.05),月经周期正常率、排卵率和妊娠率均高于对照组(P均0.01)。结论二甲双胍联合利格列汀治疗PCOS效果较好,尤其适合肥胖且有生育要求的PCOS患者。
[Abstract]:Objective to observe the efficacy of metformin combined with riglutin in the treatment of polycystic ovary syndrome (PCOS). Methods one hundred and nineteen patients with PCOS were randomly divided into control group (n = 57) and observation group (n = 62). Both groups were treated with metformin. The initial dose of metformin was 0.25 g / d and increased to 0.5 g / d after tolerance. In the observation group, the body mass of the two groups was compared after 5 mg/ d. 6 months, fasting blood glucose, postprandial blood glucose 2 h, fasting insulin FINSN, serum lipids TCTGN HDL-CU, endocrine hormone E2TFSHSHLH) were measured, and the patients' menstrual cycle was monitored. Ovulation and pregnancy. Results after 6 months of treatment, the scores of BMIFINSHOMA-IRN TCHHOMA- 尾 LHH / FSH, testosterone and hirsutism in the observation group were significantly lower than those in the control group (P < 0.01), and the normal menstrual cycle rate, ovulation rate and pregnancy rate were higher than those in the control group (P < 0.01). Conclusion Metformin combined with riglitatin is effective in the treatment of PCOS, especially for obese and fertile PCOS patients.
【作者单位】：徐州市肿瘤医院;
【基金】：徐州市社会发展项目(XZZD1249)
【分类号】：R711.75

【参考文献】