抗苗勒管激素预测卵巢反应性的价值研究

发布时间：2018-05-06 15:08

本文选题：抗苗勒管激素 + 窦卵泡计数　；参考：《实用妇产科杂志》2015年08期

【摘要】：目的:评价抗苗勒管激素(AMH)对卵巢反应性的预测价值。方法:以1489例行体外受精-胚胎移植(IVF-ET)治疗的不孕患者作为研究对象,分别以获卵数≤3个和20个界定卵巢低和高反应,比较AMH和其他卵巢储备评估指标预测卵巢反应性时的受试者工作特征曲线面积(ROCAUC)。结果:预测卵巢低反应或高反应时,AMH和窦卵泡计数(AFC)的ROCAUC均相当(分别为0.867和0.860,P=0.319;0.772和0.753,P=0.287),且明显大于年龄、基础卵泡刺激素(FSH)和基础雌二醇(E2)的ROCAUC(分别为0.685、0.723和0.600,P均0.001;0.679、0.650和0.501,P均0.001)。AMH≤8.5 pmol/L或AFC≤9时可较好地预测卵巢低反应,而AMH29.77 pmol/L或AFC16时则可较好地预测卵巢高反应。结论:AMH独立预测卵巢反应性的价值与AFC相当,二者均明显优于年龄、基础FSH和基础E2。
[Abstract]:Objective: To evaluate the predictive value of anti Mullerian hormone (AMH) on ovarian responsiveness. Methods: 1489 cases of infertile patients treated with in vitro fertilization and embryo transfer (IVF-ET) were used as research subjects, with the number of ovum less than 3 and 20 to define ovarian low and high reaction, and to compare AMH and their ovarian reserve evaluation indexes to predict ovarian responsiveness. Results: AMH and sinus oval count (AFC) were equal (0.867 and 0.860, P=0.319; 0.772 and 0.753, P=0.287) in the prediction of ovarian response to low or high response (AFC), and significantly greater than age, and ROCAUC of basal follicle stimulating hormone (FSH) and basal estradiol (E2), respectively (0.685,0.723 and 0.600, P 0.001; 0). .679,0.650 and 0.501, P 0.001).AMH < 8.5 pmol/L or AFC < 9 can predict ovarian hyper response better, while AMH29.77 pmol/L or AFC16 can predict ovarian hyper response better. Conclusion: AMH independent prediction of ovarian responsiveness is equivalent to AFC, two are obviously superior to age, basal FSH and basal E2.

【作者单位】：中山大学孙逸仙纪念医院;
【基金】：2014年中山大学5010项目(编号:2014005) 2013年国家自然科学基金项目(批准号:81370680) 2013年教育部高等学校博士学科点优先发展领域项目(编号:20130171130009)
【分类号】：R714.8

【相似文献】