不同内膜准备方案对激素替代冻胚移植患者临床结局的影响

发布时间：2018-05-08 11:38

本文选题：激素替代 + 冻融胚胎移植　；参考：《中国老年学杂志》2015年19期

【摘要】：目的探讨不同激素替代(HRT)内膜准备方案冻融胚胎移植(FET)中患者的临床结局。方法按照所使用药物方案的不同,将行HRT内膜准备FET周期的486例患者,分为HRT 1组(362例,给予戊酸雌二醇治疗)和HRT 2组(124例,给予戊酸雌二醇联合17β-雌二醇治疗)。比较这两种内膜准备方法患者的基本情况与临床结局。结果 HRT 1组原取卵周期人绒毛膜促性腺激素(HCG)日的内膜厚度及HRT周期内膜厚度、HRT1组药物周期加用黄体酮日的内膜厚度均显著高于HRT 2组(P0.05)。HRT 1组的雌二醇低于HRT 2组(P0.05)。两组的胚胎种植率、临床妊娠率均无显著差异(P0.05)。两组因子宫内膜厚度7 mm发育不良而取消周期的周期取消率分别为18.51%,16.94%。随着内膜厚度的增加,所有患者的临床妊娠率、胚胎种植率逐渐升高。两组患者不同E2水平的临床妊娠率、胚胎种植率均无明显差异(P0.05)。结论对于子宫内膜薄,单纯使用戊酸E2治疗内膜厚度不理想的患者,加用17β-雌二醇后,内膜厚度增加,临床结局较理想。
[Abstract]:Objective to investigate the clinical outcome of different hormone replacement HRTs in frozen thawed embryo transfer (FET). Methods according to the different drug regimens, 486 patients undergoing HRT intimal preparation for FET cycle were divided into HRT group (n = 362, treated with estradiol valerate) and HRT group (n = 124, treated with estradiol valerate combined with 17 尾 -estradiol). To compare the basic situation and clinical outcome of these two methods of endometrial preparation. Results the intimal thickness of HRT 1 group on the day of human chorionic gonadotropin (HCG) and the HRT cycle intima thickness of HRT1 group were significantly higher than that of HRT 2 group (P 0.05) and HRT 2 group (P 0.05). There was no significant difference in embryo implantation rate and clinical pregnancy rate between the two groups. The cycle canceling rate of the two groups due to endometrial thickness 7 mm dysplasia was 18.51 and 16.94 respectively. With the increase of intimal thickness, the clinical pregnancy rate and embryo implantation rate increased gradually in all patients. There was no significant difference in clinical pregnancy rate and embryo implantation rate between the two groups. Conclusion for the patients with thin endometrium treated with E _ 2 valerate alone, the thickness of endometrium increased and the clinical outcome was satisfactory after 17 尾 -estradiol was added.
【作者单位】：贵州省人民医院生殖中心;
【分类号】：R714.8

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