多囊卵巢综合征不孕症患者血清睾酮水平变化及与机体氧化应激的关系

发布时间：2018-05-09 04:29

本文选题：多囊卵巢综合征 + 不孕症　；参考：《山东医药》2015年11期

【摘要】：目的观察多囊卵巢综合征(PCOS)不孕症患者血清睾酮(T)水平变化,并探讨其与机体氧化应激的关系。方法选择PCOS不孕症患者73例(观察组),另选同期来我院进行孕前体检的健康妇女70例(对照组),采用电化学发光法检测血清T,黄嘌呤氧化酶法检测血清超氧化物歧化酶(SOD)活性,双抗体夹心免疫酶法检测血清8-异前列腺素F2a(8-iso-PGF2a),Spearman法分析T与SOD、8-iso-PGF2a的关系。结果观察组血清T水平为(1.04±0.69)μg/L、SOD活性为(57.57±9.28)U/m L、8-iso-PGF2a为(187.22±21.82)ng/L,对照组分别为(0.28±0.15)μg/L、(100.73±14.48)U/m L、(66.13±7.85)ng/L,两组比较,P均0.01。相关性分析显示,血清T与SOD活性呈负相关、与8-iso-PGF2α呈正相关(r分别为-0.631、0.687,P均0.05)。结论 PCOS不孕症患者血清T水平升高,机体氧化应激状态的异常可能是T水平升高的原因。
[Abstract]:Objective to observe the changes of serum testosterone (T) levels in infertile women with polycystic ovary syndrome (PCOS) and to explore the relationship between serum testosterone and oxidative stress. Methods 73 patients with PCOS infertility (observation group) and 70 healthy women (control group) who were examined before pregnancy in our hospital were selected. The activity of serum superoxide dismutase (SOD) was detected by electrochemiluminescence (ECL) and xanthine oxidase (xanthine oxidase method). Serum 8-iso-PGF2a was detected by double antibody sandwich immunoenzymatic method. The relationship between T and SOD 8-iso-PGF2a was analyzed by Spearman method. Results the serum T level of the observation group was 1.04 卤0.69 渭 g / L, the activity of sod was 57.57 卤9.28)U/m / L, 8-iso-PGF2a was 187.22 卤21.82ng / L, and that of the control group was 0.28 卤0.15 渭 g / L, 100.73 卤7.85ng / L, respectively (P < 0.01). Correlation analysis showed that serum T was negatively correlated with SOD activity, and positively correlated with 8-iso-PGF2 伪. Conclusion the elevated serum T level in PCOS infertility patients may be due to the abnormal state of oxidative stress.
【作者单位】：潍坊市妇幼保健院;潍坊市滨海区妇幼保健院;昌乐县营丘中心卫生院;
【基金】：潍坊市科学技术发展计划项目(201302039)
【分类号】：R711.75

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