益气养阴方剂对妊娠期糖尿病患者脂肪因子、胰岛β细胞功能及妊娠结局的影响

发布时间：2018-05-11 17:59

本文选题：益气养阴方剂 + 妊娠期糖尿病　；参考：《现代中西医结合杂志》2016年35期

【摘要】：目的观察益气养阴方剂对妊娠期糖尿病(GDM)患者脂肪因子、胰岛β细胞功能及妊娠结局的影响。方法将160例GDM患者随机分为观察组80例和对照组80例,对照组给予常规西医治疗,观察组在对照组治疗基础上给予益气养阴方剂治疗,2组均治疗至患者有分娩先兆时停止用药。观察2组治疗前后血清脂肪细胞因子、胰岛β细胞功能的变化及妊娠结局。结果 2组治疗后血清内脂素均明显升高(P均0.05),而脂联素、抵抗素、瘦素水平均显著降低(P均0.05),且观察组各指标改善情况均明显优于对照组(P均0.05);2组治疗后空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FINS)均明显降低(P均0.05),而胰岛素分泌指数(HOMA-β)、胰岛素敏感指数(ISI)均明显升高(P均0.05),且观察组上述指标改善情况均明显优于对照组(P均0.05);观察组不良妊娠结局率显著低于对照组(P均0.05)。结论益气养阴方剂能够显著降低GDM患者脂肪因子水平,改善患者胰岛β细胞功能,减轻胰岛素抵抗,并降低不良妊娠结局发生率。
[Abstract]:Objective to observe the effects of Yiqi Yangyin recipe on adipogenic factors, islet 尾-cell function and pregnancy outcome in patients with gestational diabetes mellitus (GDM). Methods one hundred and sixty patients with GDM were randomly divided into observation group (n = 80) and control group (n = 80). The control group was treated with routine western medicine. The changes of serum adipocytokines, islet 尾-cell function and pregnancy outcome were observed before and after treatment in both groups. Results after treatment, serum adiponectin was significantly increased in both groups (P < 0.05), while adiponectin and resistin were significantly increased in both groups. Leptin levels were significantly decreased in both groups, and the improvement of each index in the observation group was significantly better than that in the control group (P 0.05). The levels of FBGG, HbA1cN, HOMA-IRN, FINS were significantly lower in the observation group than those in the control group (P < 0.05). The insulin secretion index (HOMA- 尾) and insulin sensitivity index (ISI) were significantly increased, and the improvement of the above indexes in the observation group was significantly better than that in the control group (P < 0.05), and the adverse pregnancy outcome rate in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion Yiqi Yangyin prescription can significantly reduce the level of fat factor in patients with GDM, improve the function of islet 尾 cells, alleviate insulin resistance, and reduce the incidence of adverse pregnancy outcomes.
【作者单位】：陕西省肿瘤医院;陕西省西安市长安医院;
【分类号】：R714.256

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