围产期感染及分娩方式与胎龄对新生儿免疫功能的影响研究

发布时间：2018-05-12 04:15

本文选题：感染 + 分娩方式　；参考：《中华医院感染学杂志》2015年09期

【摘要】：目的探究新生儿免疫功能及围产期高危感染、分娩方式与胎龄的关系,为临床围产期感染预防提供依据。方法选取2011年1月-2014年1月单胎分娩的孕产妇1 600例,根据围产期是否有高危感染因素分为高危组和对照组,根据分娩方式不同分为剖宫产组和阴道产组,根据是否早产分为早产组和非早产组,测定并比较新生儿脐带血中免疫球蛋白IgA、IgG、IgM和补体C3、C4的水平。结果高危组的IgA、IgM的水平高于对照组,差异有统计学意义(P0.05);而高危组的IgG水平与非对照组的差异无统计学意义;补体C3、C4水平的比较,高危组的C3水平显著低于对照组,差异有统计学意义(P0.05);高危组C4水平与对照组差异无统计学意义;阴道产组的新生儿IgG水平高于剖宫产组的新生儿,比较差异有统计学意义(P0.05);而阴道产组的IgA、IgM及补体C3、C4和剖宫产组差异均无统计学意义;早产组与非早产组IgA、IgM差异均无统计学意义;而早产组IgG水平显著低于非早产组,差异有统计学意义(P0.05);早产组补体C3、C4水平均低于非早产组,比较差异有统计学意义(P0.05)。结论围产期感染高危因素与新生儿感染密切相关,分娩方式对新生儿免疫功能基本无影响,胎龄不足的新生儿免疫功能发育不足。
[Abstract]:Objective to explore the relationship between neonatal immune function, perinatal high risk infection, delivery mode and gestational age, and to provide evidence for clinical prevention of perinatal infection. Methods 1,600 pregnant women with single delivery from January 2011 to January 2014 were divided into high risk group and control group according to perinatal risk factors, and divided into cesarean section group and vaginal delivery group according to different delivery mode. According to whether preterm delivery is divided into preterm and non-preterm delivery groups, the levels of IgA- IgGG IgM and complement C _ 3 C _ 4 in umbilical cord blood of newborns were measured and compared. Results the level of IgA IgG in high risk group was higher than that in control group, the difference was statistically significant (P 0.05), but the level of IgG in high risk group was not significantly different from that in non-control group, and the C3 level in high risk group was significantly lower than that in control group. There was no significant difference in C4 level between the high risk group and the control group, and the IgG level in the vaginal delivery group was higher than that in the caesarean section group. There was no significant difference in IgAM-IgM, complement C3C4-4 and cesarean section in vaginal delivery group, but there was no significant difference between preterm delivery group and non-preterm delivery group, but IgG level in preterm delivery group was significantly lower than that in non-preterm delivery group, but there was no significant difference between preterm delivery group and non-preterm delivery group. The level of complement C _ 3 C _ 4 in premature delivery group was lower than that in non-preterm delivery group, and the difference was statistically significant (P 0.05). Conclusion the high risk factors of perinatal infection are closely related to neonatal infection.
【作者单位】：绍兴第二医院妇产科分娩室;绍兴市妇幼保健院产科;
【基金】：浙江省医药卫生科学研究基金资助项目(2009A007)
【分类号】：R714.7

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