孕期健康和环境暴露对牙发育的影响

发布时间：2018-05-15 06:45

  本文选题：牙发育 + 孕期健康　； 参考：《华西口腔医学杂志》2017年04期

【摘要】：牙发育是复杂信号网络调控的牙源性上皮和神经嵴来源牙源性间充质之间交互作用的结果,遗传因素及环境因素在此过程中均发挥重要作用。母体是胎儿生长发育的主要载体,孕期母体健康和环境暴露对胎儿和儿童牙发育具有较大影响。本文根据不同类型的孕期母体环境因素,重点从环境内分泌干扰物、多种化学物质的联合作用及母体健康等三个方面对胎儿和儿童牙发育的关键问题进行综述,探讨了孕期环境因素在釉质发育缺陷、磨牙切牙矿化不全、氟牙症、多生牙及先天性缺牙等牙发育异常中的作用,为从生命早期预防牙发育异常、评估牙发育异常风险、进行牙发育相关咨询、促进儿童口腔健康管理提供理论依据。
[Abstract]:Tooth development is the result of interaction between odontogenic epithelium regulated by complex signal network and odontogenic mesenchymal derived from neural crest. Genetic and environmental factors play an important role in this process. Maternal body is the main carrier of fetal growth and development. Maternal health and environmental exposure during pregnancy have great influence on the development of fetus and children's teeth. According to different maternal environmental factors during pregnancy, the key issues of fetal and child tooth development were reviewed from three aspects: environmental endocrine disruptors, combined effects of various chemicals and maternal health. The role of environmental factors in enamel development defect, molar incisor mineralization, fluorosis, multiple teeth and congenital tooth defects was discussed in order to prevent tooth development abnormality and evaluate the risk of tooth development abnormality from the early life stage. To provide theoretical basis for dental development counseling to promote oral health management of children.
【作者单位】： 口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院;
【基金】：国家自然科学基金面上项目(81470711,81371136)~~
【分类号】：R714.2
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本文编号：1891410