环氧化酶2抑制剂抗卵巢癌作用的研究进展

发布时间：2018-05-16 00:25

本文选题：卵巢癌 + Cox-　；参考：《现代妇产科进展》2015年11期

【摘要】：卵巢癌是妇科常见的恶性肿瘤之一,由于起病隐匿。现有的化疗方案常由于化疗药物不敏感、耐药等原因导致肿瘤易复发,化疗毒副反应大而使卵巢癌的死亡率一直居高不下,因而寻找一种安全、有效的化疗方案一直是妇科肿瘤工作者面临的难题。Cox-2的表达水平与卵巢癌分型、分化程度、转移密切相关,直接影响卵巢癌患者的预后,对判断卵巢肿瘤的恶性度有一定的提示作用,是卵巢癌治疗中的一个潜在的靶点。Cox-2抑制剂可通过PI3K/Akt、NF-κB、Fas L、RAS/RAF/MAPK/ERK等多种途径促进肿瘤细胞凋亡,抑制细胞增殖,抑制血管生成,从而发挥抗肿瘤作用。Cox-2抑制剂还可与化疗药物协同作用,提高化疗药物的敏感性、减少耐药,增强化疗效果。本文就cox-2抑制剂在卵巢癌治疗中的研究现状作以总结。
[Abstract]:Ovarian cancer is one of the most common malignant tumors in gynecology. The current chemotherapy regimens are often due to the insensitivity of chemotherapeutic drugs, drug resistance and other reasons leading to the recurrence of tumors. The mortality rate of ovarian cancer is always high because of the large side effects of chemotherapy, so it is safe to seek a kind of safety. Effective chemotherapy regimen is always a difficult problem for gynecologic oncology workers. Cox-2 expression level is closely related to ovarian cancer classification, differentiation, metastasis, and directly affects the prognosis of ovarian cancer patients. It is a potential target in the treatment of ovarian cancer. Cox-2 inhibitor can promote apoptosis, inhibit cell proliferation and inhibit angiogenesis through various pathways such as PI3K / AktNF- 魏 FASR RASR / RAFR / MAPK / ERK, etc. Thus, the anti-tumor effect of .Cox-2 inhibitor can be combined with chemotherapeutic drugs to increase the sensitivity of chemotherapeutic drugs, reduce drug resistance and enhance the chemotherapeutic effect. In this paper, the research status of cox-2 inhibitors in ovarian cancer treatment is summarized.
【作者单位】：中日友好医院妇产科;
【基金】：国家自然科学基金项目(No:81372777,81372779)
【分类号】：R737.31

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