CX43蛋白在子宫内膜息肉中的表达及意义

发布时间：2018-05-16 12:51

本文选题：CX + 高血压　；参考：《西安交通大学学报(医学版)》2016年05期

【摘要】：目的探讨CX43蛋白在子宫内膜息肉(EP)中的表达及意义。方法随机选取存档石蜡标本共79例,为2011年1月至2013年5月于西安交通大学第二附属医院妇产科就诊的EP及因其他子宫内膜疾病诊刮患者的术后病检组织,其中病例组共44例EP组织(其中增殖期18例,分泌期15例,绝经后11例),对照组共35例正常子宫内膜组织(其中增殖期12例,分泌期12例,绝经后11例)。采用免疫组化法检测CX43蛋白在正常子宫内膜及EP绝经前、后期的表达情况,并分析与临床指标的关系。结果对照组及EP组中CX43蛋白的表达可见于子宫内膜腺上皮细胞及腺体周围的间质细胞中。EP组CX43蛋白阳性率较对照组降低,差异有统计学意义(P0.05)。CX43蛋白在增殖期和分泌期EP中的阳性率相近,在绝经后EP中的阳性率较绝经前降低,但差异均无统计学意义(P0.05)。EP中CX43蛋白的阳性表达与高血压及息肉数目无相关性。结论 CX43蛋白在EP中的表达降低,在EP发生发展过程中可能起着重要作用。
[Abstract]:Objective to investigate the expression and significance of CX43 protein in endometrial polyps. Methods from January 2011 to May 2013, 79 paraffin wax specimens were randomly selected from EP patients in the second affiliated Hospital of Xi'an Jiaotong University and postoperative biopsy tissues of patients with other endometrial diseases, who were treated with gynecology and obstetrics in the second affiliated Hospital of Xi'an Jiaotong University from January 2011 to May 2013. There were 44 cases of EP in the case group (18 cases in proliferative phase, 15 cases in secretory phase, 11 cases in postmenopausal phase) and 35 cases in control group (12 cases in proliferative phase, 12 cases in secretory phase and 11 cases in postmenopausal stage). Immunohistochemical method was used to detect the expression of CX43 protein in normal endometrium and premenopausal and postmenopausal period, and to analyze the relationship between the expression of CX43 protein and clinical indexes. Results the expression of CX43 protein in the control group and EP group was lower than that in the control group. The positive rate of CX43 protein in the endometrial glandular epithelial cells and stromal cells around the glandular epithelium was lower than that in the control group. The positive rate of P0.05. CX43 protein was similar in proliferative phase and secretory phase, and decreased in postmenopausal EP, and the positive rate of CX43 protein in postmenopausal EP was lower than that in postmenopausal EP. The positive expression of CX43 protein was not correlated with hypertension and the number of polyps. Conclusion the decreased expression of CX43 protein in EP may play an important role in the development of EP.
【作者单位】：西安交通大学第二附属医院妇产科;
【基金】：陕西省自然科学基金资助项目(No.2013JM4012)~~
【分类号】：R711.74

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