血浆肾上腺髓质素水平对早期异位妊娠的诊断价值

发布时间：2018-05-16 14:58

本文选题：肾上腺髓质素 + 妊娠早期　；参考：《上海交通大学学报(医学版)》2015年07期

【摘要】：目的探讨血浆中肾上腺髓质素(ADM)在早期异位妊娠中变化情况,研究其对异位妊娠早期诊断的价值。方法选取2014年3月—12月在上海交通大学医学院附属国际和平妇幼保健院及上海市虹口区江湾医院收治的50例停经5~7周的异位妊娠患者为研究对象,另选取140名正常宫内妊娠者为正常对照组,绘制散点图,观察ADM水平与停经周数的相关性;利用受试者工作特征(ROC)曲线分析ADM的临界点。结果 1140例正常对照组血浆ADM水平总体趋势是随停经周数的增加而增加,相关系数r为0.283(P0.05)。250例异位妊娠组血浆ADM水平一直处于低值状态,随着停经周数的增加变化不明显,r值为0.186(P0.05)。3异位妊娠组停经7周的中位数倍数明显低于正常对照组(P0.05)。4应用ROC曲线分析ADM诊断异位妊娠的临界值(P0.05)。结论早期异位妊娠者血浆ADM水平处于低值状态,随停经周数变化不明显,但作为异位妊娠早期诊断的指标无统计学意义(P0.05)。
[Abstract]:Objective to investigate the changes of adrenal medullin (ADM) in early ectopic pregnancy and its value in early diagnosis of ectopic pregnancy. Methods from March to December 2014, 50 ectopic pregnancy patients who were admitted to the International Peace Maternal and Child Health Institute of Shanghai Jiaotong University School of Medicine and Jiangwan Hospital, Hongkou District, Shanghai, were selected as subjects. In addition, 140 normal intrauterine pregnant women were selected as the normal control group, the scattered plot was drawn to observe the correlation between ADM level and menopause weeks, and the critical point of ADM was analyzed by using the operating characteristics of the subjects. Results the general trend of plasma ADM level in 1140 normal controls was increased with the increase of menopausal weeks. The correlation coefficient r was that the plasma ADM level of 0.283(P0.05).250 patients with ectopic pregnancy was always low. With the increase of the number of menopausal weeks, there was no significant change in r value: the median multiple of 7 weeks in 0.186(P0.05).3 ectopic pregnancy group was significantly lower than that in normal control group (P0.054.The critical value of ADM for diagnosing ectopic pregnancy was analyzed by ROC curve). Conclusion the level of plasma ADM in early ectopic pregnancy patients is in a low state, but there is no significant change with the number of menopausal weeks, but as an indicator of early ectopic pregnancy, there is no significant difference (P 0.05).
【作者单位】：上海市虹口区江湾医院妇产科;上海交通大学医学院附属国际和平妇幼保健院妇产科;
【基金】：上海市虹口区优青培养项目(2013) 上海交通大学“新百人计划”研究项目(XBR2013097) 上海市卫生局基金(20124027) 上海市市级医院适宜技术(SHDC12014208) 上海市科委医学引导项目(15411961100)~~
【分类号】：R714.22

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