卵巢早衰与非早衰者受卵IVF-ET治疗结局分析

发布时间：2018-05-16 15:45

本文选题：赠、受卵 + 赠卵数目　；参考：《郑州大学学报(医学版)》2016年03期

【摘要】：目的:探讨卵巢早衰(POF)、非POF患者受卵IVF-ET的治疗结局及影响因素。方法:回顾性分析2012年11月至2015年1月于郑州大学第一附属医院生殖医学中心行受卵冻融胚胎移植助孕的267例POF、非POF患者和267例同期行赠卵IVF/ICSI患者的治疗情况及妊娠结局。结果:POF、非POF受卵者每个IVF周期的受卵数分别为3.98、4.13个。赠卵者新鲜移植胚胎周期和解冻移植胚胎周期的临床妊娠率分别为52.50%、63.53%,受卵POF组、非POF组解冻移植胚胎周期的临床妊娠率分别为62.96%、51.59%,4组间差异无统计学意义(P=0.099)。受卵非POF解冻移植胚胎周期的单胎活产率低于赠卵新鲜移植胚胎周期和解冻移植胚胎周期(P0.05)。赠、受双方IVF/ICSI周期的受精率、胚胎形成率、优质胚胎形成率及胚胎移植周期的胚胎种植率比较,差异均无统计学意义(P0.05)。结论:赠卵IVF-ET治疗中适当减少赠卵数并不影响赠、受卵者的治疗结局。
[Abstract]:Objective: to investigate the outcome and influencing factors of IVF-ET in patients with premature ovarian failure (POF) and non-POF. Methods: from November 2012 to January 2015, 267 cases of POF, non POF patients and 267 cases of IVF/ICSI patients who were treated with egg freeze-thawed embryo transfer at the Center of Reproductive Medicine, the first affiliated Hospital of Zhengzhou University, were retrospectively analyzed. Results the number of recipient eggs per IVF cycle was 3.98 / 4.13 for non-POF recipients. The clinical pregnancy rates of fresh embryo transfer cycle and thawed embryo transfer cycle were 52.50 and 63.53, respectively. The clinical pregnancy rates of thawed embryo transfer cycle in POF group and non-POF group were 62.96 ~ 51.5910%, respectively. There was no significant difference among the four groups. The single embryo delivery rate in the unthawed embryo cycle was lower than that in the fresh embryo transfer cycle and thawed transfer embryo cycle (P0.05). There was no significant difference in fertilization rate, embryo formation rate, high quality embryo formation rate and embryo implantation rate of embryo transfer cycle between recipients and recipients of IVF/ICSI cycle (P 0.05). Conclusion: proper reduction of the number of donated eggs in the treatment of egg donation IVF-ET does not affect the outcome of the treatment of the recipient.
【作者单位】：郑州大学第一附属医院生殖医学中心;
【分类号】：R714.8

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