扩散加权成像在正常胎儿脑发育中的应用

发布时间：2018-05-17 05:01

本文选题：胎儿 + 脑发育　；参考：《临床放射学杂志》2015年03期

【摘要】：目的探讨扩散加权成像(DWI)对正常胎儿脑发育的评估价值。方法回顾性分析40例正常胎儿脑DWI表现,孕周19~39周,平均33.6周。在ADC图上分析总结正常胎儿脑表现特征,并测量脑干、双侧小脑半球、基底节区、丘脑、颞叶白质、额叶白质、枕叶白质、半卵圆中心及顶叶白质的ADC值,分析不同部位ADC值随孕周变化的规律。结果在ADC图上,胎儿幕上脑实质表现为信号强度不同的分层状结构,随孕周增加分层减少。双侧大脑半球间对称部位ADC值无显著性差异。幕上深部白质平均ADC值高于小脑半球、脑干及深部灰质核团,顶叶ADC值最高(1.62±0.17)mm/s,脑干ADC值最低(1.08±0.13)mm/s。胎儿脑干、双侧小脑半球、基底节区、丘脑、颞叶白质、枕叶白质、半卵圆中心及顶叶白质ADC值与胎龄呈负相关,小脑半球相关系数最高(r=0.78),枕叶相关系数最低(r=0.38),额叶与胎龄无线性相关(P0.05)。小脑半球ADC值随胎龄增长下降最快(b=0.03)。结论 DWI可应用于正常胎儿脑发育的评估,为胎儿脑发育的产前诊断及预后提供重要信息。
[Abstract]:Objective to evaluate the value of diffusion-weighted imaging (DWI) in normal fetal brain development. Methods the DWI findings of 40 normal fetuses were analyzed retrospectively. The gestational age was 1939 weeks (mean 33. 6 weeks). The features of normal fetal brain were analyzed and summarized on ADC map, and the ADC values of brain stem, bilateral cerebellar hemisphere, basal ganglia, thalamus, temporal white matter, frontal white matter, occipital white matter, centrum semiovale and parietal white matter were measured. The changes of ADC in different parts with gestational weeks were analyzed. Results on ADC, the parenchyma of supratentorial fetal brain showed a layered structure with different signal intensity, and decreased with the increase of gestational week. There was no significant difference in ADC between the two hemispheres. The mean ADC value of the deep supratentorial white matter was higher than that of the cerebellar hemisphere, brain stem and deep gray nucleus. The highest ADC value in the parietal lobe was 1.62 卤0.17 mm / s, and the lowest ADC value in the brain stem was 1.08 卤0.13 mm / s. In fetal brain stem, bilateral cerebellar hemisphere, basal ganglia, thalamus, temporal white matter, occipital white matter, semioval center and parietal white matter were negatively correlated with gestational age. The correlation coefficients of cerebellar hemisphere and occipital lobe were the highest 0.78 and 0.38, respectively, and the wireless correlation between frontal lobe and gestational age was P 0.05. The ADC value of cerebellar hemisphere decreased the fastest with the increase of gestational age. Conclusion DWI can be used to evaluate normal fetal brain development and provide important information for prenatal diagnosis and prognosis of fetal brain development.
【作者单位】：广州医科大学;南方医科大学附属深圳市妇幼保健院放射科;
【分类号】：R445.2;R714.5

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