miRNA-21在子宫颈鳞癌组织中表达的初步研究

发布时间：2018-05-17 04:09

本文选题：微小分子RNA + 子宫颈癌　；参考：《中国妇产科临床杂志》2015年02期

【摘要】：目的探讨微小分子RNA(microRNA-21,miR-21)在宫颈癌患者组织中的表达情况。方法选择宫颈鳞癌20例作为宫颈癌组,其中12例HPV16阳性,8例HPV16阴性;正常宫颈16例作为对照组,采用实时定量PCR方法检测miR-21在各组中的表达情况。结果 MiR-21在宫颈癌和对照组中的相对表达量为4.019±0.002;MiR-21在HPV16阳性宫颈癌组和阴性组的相对表达量分别为2.376±0.034和2.002±0.024,差异有统计学意义(P0.05)。结论 miR-21在宫颈癌组织中呈高表达,可能与宫颈癌发生、发展有关。
[Abstract]:Objective to investigate the expression of microRNA-21 miR-21 in patients with cervical cancer. Methods Twenty cases of cervical squamous cell carcinoma were selected as cervical cancer group, of which 12 cases were HPV16 positive and 8 cases were HPV16 negative, and 16 cases of normal cervix as control group. The expression of miR-21 in each group was detected by real-time quantitative PCR. Results the relative expression of MiR-21 in cervical carcinoma and control group was 2.376 卤0.034 and 2.002 卤0.024, respectively (P 0.05). Conclusion there is a high expression of miR-21 in cervical carcinoma, which may be related to the occurrence and development of cervical cancer.
【作者单位】：上海交通大学附属第六人民医院南院妇科微创;
【基金】：上海市奉贤区科委资助项目(2012-1003)
【分类号】：R737.33

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