妊娠中期甲状腺功能状态与妊娠糖尿病的关系

发布时间：2018-05-17 16:30

本文选题：妊娠糖尿病 + 甲状腺激素　；参考：《上海交通大学学报(医学版)》2015年08期

【摘要】：目的了解妊娠期血糖水平与促甲状腺素(TSH)之间是否具有相关性,并评估妊娠期间甲状腺激素及甲状腺自身抗体的水平在筛查妊娠糖尿病(GDM)中的作用。方法随机选取在重庆医科大学附属第一医院产检的孕14~28周妇女265名,测定血清TSH、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TpoAb)水平,并于孕28周行75 g OGTT检查,统计GDM的发病率,GDM发病率与TpoAb水平之间的相关性、TSH与OGTT各时间点血糖水平的相关性分析采用Spearman秩相关分析。结果 1妊娠中期GDM发病率为19.2%,总的甲状腺功能异常发病率为3.8%,TpoAb阳性率为6.8%。2妊娠中期GDM的发病与TSH值之间没有相关性。3妊娠中期GDM的发病与TpoAb是否阳性没有相关性(P=0.774)。4GDM者的甲状腺功能和自身抗体与非GDM者无显著差别。结论尚无明确证据支持妊娠甲状腺疾病与GDM之间存在相互性,临床工作中应对两种疾病单独筛查,避免漏诊。
[Abstract]:Objective to understand the correlation between blood glucose level in pregnancy and thyrotropin (TSH), and to evaluate the role of thyroid hormone and thyroid autoantibody in screening pregnancy diabetes (GDM) during pregnancy. Methods 265 pregnant women with 14~28 weeks in First Affiliated Hospital of Chongqing Medical University were randomly selected and serum TS was measured. H, free three iodide adenosine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TpoAb) level, and 75 g OGTT examination at 28 weeks of pregnancy. The incidence of GDM, the correlation between the incidence of GDM and the level of TpoAb, the correlation analysis of the level of blood sugar in TSH and OGTT at each time point was analyzed by Spearman rank correlation analysis. Results 1 pregnancy The incidence of mid-term GDM was 19.2%, the total incidence of abnormal thyroid function was 3.8%, the positive rate of TpoAb was 6.8%.2 in the mid-term of pregnancy and TSH, there was no correlation between the pathogenesis of GDM in the mid-term pregnancy and the positive of TpoAb (P=0.774). There was no significant difference between the thyroid function and the autoantibody and the non GDM in the thyroid function of the.4GDM. Clear evidence supports the existence of interrelationship between thyroid disease and GDM in pregnancy. In clinical work, two diseases should be screened separately to avoid missed diagnosis.
【作者单位】：重庆医科大学附属第一医院内分泌科;
【基金】：国家临床重点专科建设项目(2011) 重庆市渝中区科技计划项目(20140127)~~
【分类号】：R714.256

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