一家系4例子宫内膜癌报告

发布时间：2018-05-17 16:39

本文选题：子宫内膜癌 + 家族遗传性　；参考：《四川大学学报(医学版)》2017年02期

【摘要】：目的探讨遗传性子宫内膜癌的发病特点,为遗传性子宫内膜癌的筛查、预防及诊治提供临床依据。方法回顾性分析我院收治的同一家系两代4例子宫内膜癌患者的临床病理资料。结果同一家系两代子宫内膜癌患者共4例,先证者因阴道不规则出血就诊,4年后该家族另外3人(其母、两个妹妹)于同一年内先后发现子宫内膜癌,4例患者发病年龄44~75岁,平均52.3岁。其母亲发病在绝经后,三姐妹发病均在绝经前。三姐妹中2例因不规则阴道出血就诊,1例体检时发现子宫内膜癌就诊,其母亲因绝经后不规则阴道出血就诊。4例患者均在术前诊刮病理检查即发现子宫内膜癌;所有患者均进行了手术+化疗治疗,术后均恢复良好,随访至今均全部存活,未发现复发。结论遗传性子宫内膜癌发病时间早、发病率较高,早发现及早治疗预后较好。
[Abstract]:Objective to investigate the characteristics of hereditary endometrial carcinoma and to provide clinical basis for screening, prevention, diagnosis and treatment of hereditary endometrial carcinoma. Methods the clinicopathological data of 4 patients with endometrial carcinoma from two generations of the same family in our hospital were analyzed retrospectively. Results there were 4 patients with endometrial carcinoma in the same family and two generations. The proband was treated with irregular vaginal bleeding. Four patients with endometrial carcinoma were found in the same family four years later at the age of 4475 years. The average age is 52.3 years. Her mother developed the disease after menopause, and the three sisters were all premenopausal. Two of the three sisters were diagnosed with irregular vaginal bleeding and one patient was diagnosed with endometrial carcinoma during physical examination, while the mother of 4 patients with irregular postmenopausal vaginal hemorrhage was found endometrial carcinoma by pathological examination before operation. All patients were treated with surgical chemotherapy and recovered well. All patients survived and no recurrence was found. Conclusion hereditary endometrial carcinoma has an early onset and high incidence, and early detection and early treatment have a good prognosis.
【作者单位】：四川大学华西第二医院妇产科出生缺陷与相关妇儿疾病教育部重点实验室;
【分类号】：R737.33

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