CA125在上皮性卵巢癌中的表达及其与预后的相关性分析

发布时间：2018-05-18 00:22

本文选题：CA + 上皮性卵巢癌　；参考：《上海交通大学学报(医学版)》2015年09期

【摘要】：目的探讨CA125在上皮性卵巢癌中的表达及其与预后的相关性。方法回顾性分析247例确诊为上皮性卵巢癌患者的临床资料,所有患者至少随访5年或随访至死亡。采用化学发光免疫法检测CA125,并划分为q1、q2、q3和q4共4个区间。比较CA125在不同临床病理特征患者中的表达差异,比较4个区间的生存情况。采用Logistic回归分析预后因素。结果 CA125在年龄、病理类型、FIGO分期、组织学分化和术后残留病灶大小不同的病例中的表达均具有统计学意义(P0.05)。q1、q2、q3和q4区间的中位生存期分别为58、40、19和11个月,5年生存率分别为48.4%(30/62)、32.3%(20/62)、21.0%(13/62)和11.5%(7/61),差异均具有统计学意义(P0.05)。Logistic回归分析显示,与q1比较,q2、q3和q4预后死亡的OR(95%CI)分别为1.624(1.445~1.825)、2.447(1.785~3.355)和4.121(2.624~6.472)。结论 CA125表达与上皮性卵巢癌不同临床病理特征具有相关性,术前CA125可作为上皮性卵巢癌预后的独立预测因子。
[Abstract]:Objective to investigate the expression of CA125 in epithelial ovarian carcinoma and its correlation with prognosis. Methods Clinical data of 247 patients with epithelial ovarian cancer were retrospectively analyzed. All patients were followed up for at least 5 years or until death. CA125 was detected by chemiluminescence immunoassay and divided into 4 sections: Q1, Q2, Q3 and Q4. To compare the expression of CA125 in patients with different clinicopathological features and to compare the survival of the four regions. Prognostic factors were analyzed by Logistic regression analysis. Results the age, pathological type and Figo stage of CA125 were analyzed. There were significant differences in the expression of histological differentiation and postoperative residual lesions in patients with different sizes of residual lesions. The median survival time was 58,4019 and 11 months, respectively. The 5-year survival rates were 48.4% 30% 62% 32.3% 20% 6221.0% 1362% and 11.5% 761%, respectively. The difference was statistically significant. Logistic regression analysis showed that, Compared with Q1, the OR-95CIs of prognosis death of Q2Q3 and Q4 were 1.6241445 ~ 1.825 ~ 2.447 ~ 1.785 ~ 3.355) and 4.121 ~ 2.624 ~ 6.472C respectively. Conclusion CA125 expression is correlated with different clinicopathological features of epithelial ovarian cancer. Preoperative CA125 may be an independent predictor of prognosis of epithelial ovarian cancer.
【作者单位】：上海交通大学医学院附属国际和平妇幼保健院妇科;
【分类号】：R737.31

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