不同方案GnRH-a降调节对轻中度子宫内膜异位症患者体外受精-胚胎移植结局的影响

发布时间：2018-05-18 04:36

本文选题：促性腺激素释放激素激动剂 + 子宫内膜异位症　；参考：《实用妇产科杂志》2017年11期

【摘要】：目的:探讨不同方案促性腺激素释放激素激动剂(GnRH-a)对轻中度子宫内膜异位症(EMT)患者行体外受精-胚胎移植(IVF-ET)的助孕结局的影响。方法:选择成都市妇女儿童中心医院生殖中心269个IVF助孕周期(175例患者)进行回顾性分析,按GnRH-a的不同方案进行分组:超长方案组75例共102个周期(长效GnRH-a 3.75 mg)、长效长方案组69例共87个周期(长效GnRH-a 1.875 mg)及短效长方案组31例共80个周期(GnRH-a 0.1 mg)。比较3种降调节方案的助孕情况及妊娠结局。结果:超长方案组中Gn用量及Gn天数均多于长效长方案组及短效长方案组,差异有统计学意义(P0.05)。长效长方案组胚胎种植率、生化妊娠率及临床妊娠率高于超长方案组及短效长方案组,差异有统计学意义(P0.05),超长方案组与短效方案组相比,差异无统计学意义(P0.05)。结论:对于接受IVF助孕的轻中度EMT患者采用长效长方案降调节可能更有利于提高EMT不孕患者的临床妊娠率。
[Abstract]:Aim: to investigate the effect of gonadotropin releasing hormone agonist (GnRH-a) on the outcome of IVF-ETT in patients with mild to moderate endometriosis. Methods: two hundred and sixty-nine patients with IVF in reproductive center of Chengdu Women and Children Central Hospital were selected for retrospective analysis. According to the different schemes of GnRH-a, there were 102 cycles (long-acting GnRH-a 3.75mgg) in 75 patients with super-long regimen, 87 cycles (long-acting GnRH-a 1.875 mg) in 69 patients with long-acting long-term regimen and 80 cycles (GnRH-a 0.1 mg / g) in 31 patients with short-effect long-term regimen. To compare the pregnancy aid and pregnancy outcome of three kinds of descending regulation schemes. Results: the dosage of Gn and the days of Gn in the super-long group were more than those in the long-effect group and the short-effect group, and the difference was statistically significant (P 0.05). The embryo implantation rate, biochemical pregnancy rate and clinical pregnancy rate were higher in the long-effect regimen group than in the super-long plan group and the short-effect long plan group, and the difference was statistically significant (P 0.05). There was no significant difference between the super-long regimen group and the short-effect regimen group. Conclusion: long term regimen may be more helpful to improve the clinical pregnancy rate of patients with EMT infertility in patients with mild and moderate EMT who receive IVF.
【作者单位】：成都市妇女儿童中心医院;
【分类号】：R714.8

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