硝苯地平联合硫酸镁对妊娠期高血压疾病母婴的影响研究

发布时间：2018-05-18 15:18

本文选题：硝苯地平 + 硫酸镁　；参考：《安徽医药》2016年12期

【摘要】：目的探讨硝苯地平联合硫酸镁对妊娠期高血压疾病母婴的影响。方法选取妊娠期高血压疾病患者240例,按随机数字表法随机分为联合组及对照组,每组120例。联合组患者采用硝苯地平联合硫酸镁治疗,对照组采用单用硫酸镁治疗,对比两组患者治疗后母婴情况、疗效及并发症的发生情况。结果与对照组相比,联合组患者治疗后宫缩乏力、被迫终止妊娠、产后大出血、胎儿宫内窘迫、生后窒息、围生期死亡发生率较低(P0.05)。联合组患者总有效率为92.5%,高于对照组(75.8%),差异有统计学意义(Z=12.507,P0.001)。与治疗前相比,联合组与对照组患者治疗后收缩压、舒张压、24 h尿蛋白、血液黏滞度、纤维蛋白原较低,凝血酶原时间较长(P0.05)。与对照组相比,联合组患者治疗后收缩压、舒张压、24 h尿蛋白、血液黏滞度、纤维蛋白原较低,凝血酶原时间较长(P0.001)。结论硝苯地平联合硫酸镁治疗妊娠期高血压疾病疗效佳,并发症少,预后可,值得临床推广。
[Abstract]:Objective to study the effect of nifedipine combined with magnesium sulfate on maternal and infant with hypertensive disorder complicating pregnancy. Methods 240 cases of hypertensive disorder complicating pregnancy were randomly divided into combined group and control group with 120 cases in each group. The patients in the combined group were treated with nifedipine combined with magnesium sulfate and the control group were treated with magnesium sulfate alone. Results compared with the control group, the patients in the combined group were forced to terminate pregnancy, postpartum hemorrhage, fetal distress, postnatal asphyxia, and perinatal death rate was lower than that in the control group. The total effective rate of the combined group was 92.5%, which was higher than that of the control group (75.8%). The difference was statistically significant. Compared with before treatment, systolic blood pressure, 24 h urine protein, blood viscosity, fibrinogen and prothrombin time were lower in the combined group and control group than in the control group. Compared with the control group, systolic blood pressure, 24 h urine protein, blood viscosity, fibrinogen and prothrombin time were lower in the combined group than those in the control group (P 0.001). Conclusion nifedipine combined with magnesium sulfate is effective in the treatment of hypertensive disorder complicating pregnancy.
【作者单位】：上海中医药大学附属第七人民医院;
【分类号】：R714.246

【参考文献】