辅助生殖技术发展对围产医学及子代健康的挑战

发布时间：2018-05-19 11:32

本文选题：辅助生殖技术 + 着床　；参考：《重庆医科大学学报》2017年08期

【摘要】：辅助生殖技术(assisted reproductive technology,ART)为人类繁衍带来了新的希望和方法。同时,ART的推广也为围产医学带了更多的挑战,如多胎妊娠率高、妊娠合并症发生率高、促排卵药物过度使用等相关问题。改善胚胎着床率和妊娠维持对于提高ART成功率至关重要。ART可能导致子宫内膜容受性受损,而子宫内膜容受性对胎盘滋养细胞的侵袭能力具有重要影响。因此,ART被认为是子痫前期等胎盘源性疾病的潜在风险因素,从而带来了更加复杂的胚胎早期暴露因素,可能对子代发育编程产生不良影响。进一步探明ART对子宫内膜容受性以及滋养细胞生理功能的影响,利用代谢组学等新技术对孕妇的代谢图谱进行分析,开发免疫调节治疗等手段改善胚胎着床,将有希望降低ART导致的不良妊娠结局及子代健康风险。
[Abstract]:Assisted reproductive technology (art) has brought new hope and method for human reproduction. At the same time, the promotion of art also brings more challenges to perinatal medicine, such as the high rate of multiple pregnancies, the high incidence of complications of pregnancy, the overuse of ovulation promoting drugs and so on. Improving embryo implantation rate and pregnancy maintenance is essential to improve the success rate of ART. Art may lead to endometrial receptivity damage and endometrial receptivity has an important effect on the invasion ability of placental trophoblast cells. Therefore, art is considered to be a potential risk factor for placental diseases such as preeclampsia, resulting in more complex early embryonic exposure factors, which may have a negative impact on the development of offspring programming. To further investigate the effects of ART on endometrial receptivity and trophoblastic physiological function, the metabolic map of pregnant women was analyzed by new techniques such as metabolomics, and immunomodulation therapy was developed to improve embryo implantation. There is hope of reducing the adverse pregnancy outcomes and health risks associated with ART.
【作者单位】：重庆医科大学附属第一医院妇产科重庆医科大学"中国-加拿大-新西兰"联合母胎医学实验室;
【基金】：国家自然科学基金资助项目(编号:81471472;81520108013;81671488) 重庆市教委科学技术研究资助项目(编号:KJ1500223) 重庆医科大学优秀青年基金资助项目(编号:CYYQ201507)
【分类号】：R714.8

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