血清β-绒毛膜促性腺激素与C-反应蛋白水平在预测胎膜早破宫内感染及预后评价分析

发布时间：2018-05-20 00:10

本文选题：胎膜早破 + 宫内感染　；参考：《中华医院感染学杂志》2017年05期

【摘要】：目的探讨血清β-绒毛膜促性腺激素(β-hCG)、C-反应蛋白(CRP)对胎膜早破宫内感染及预后的评价作用。方法选择2014年2月-2016年5月医院158例胎膜早破孕妇作为本次研究对象,于产前空腹抽取静脉血5ml,经离心处理后采用免疫分析法检测孕妇β-hCG及CRP水平,待产妇分娩后留取其胎膜组织及胎盘组织,根据检查判断是否存在组织绒毛膜炎,然后将研究对象分为非感染组(102例)与感染组(56例);然后再对两组血清β-hCG及CRP加以比较与分析,并评估两组预后情况。结果感染组β-hCG及CRP水平分别为(22.27±8.71)mol/ml、(29.41±9.42)mg/L,明显高于非感染组(16.15±7.18)mol/ml、(11.15±7.68)mg/L,t分别为4.74、13.17,P=0.00;血清β-hCG与CRP水平预测胎膜早破宫内感染的敏感度、准确度、特异度、阳性预测值及阴性预测值相比差异无统计学意义;血清β-hCG阳性及CRP阳性患者抗菌药物使用时间、住院时间明显长于血清β-hCG阴性及CRP阴性患者,P0.05。结论检测胎膜早破孕妇血清β-hCG与CRP水平可较好的诊断胎膜早破宫内感染,对患者预后也有一定预测价值。
[Abstract]:Objective to investigate the effect of serum 尾 -chorionic gonadotropin (尾 -hCGG-C- reactive protein) on intrauterine infection and prognosis of premature rupture of membranes. Methods from February 2014 to May 2016, 158 pregnant women with premature rupture of membranes were selected as the study subjects. The venous blood samples were collected on an empty stomach before delivery. After centrifugation, the levels of 尾 -hCG and CRP in pregnant women were detected by immunoassay. After delivery, the fetal membrane and placental tissue were taken from the parturient, and the tissue chorionitis was determined according to the examination. Then the subjects were divided into two groups: the non-infection group (n = 102) and the infection group (n = 56). Then the serum 尾 -hCG and CRP were compared and analyzed, and the prognosis of the two groups was evaluated. Results the levels of 尾 -hCG and CRP in infected group were 22.27 卤8.71mol / ml / L, 29.41 卤9.42mg / L respectively, which were significantly higher than those in non-infected group (16.15 卤7.18mol / ml) 11.15 卤7.68mg / L, respectively, and the sensitivity, accuracy, specificity of serum 尾 -hCG and CRP levels in preterm rupture of fetal membrane were predicted. There was no significant difference between positive predictive value and negative predictive value, and the duration of use of antimicrobial agents in serum 尾 -hCG positive and CRP positive patients was significantly longer than that in serum 尾 -hCG negative and CRP negative patients (P 0.05). Conclusion Detection of serum 尾 -hCG and CRP levels in pregnant women with premature rupture of membranes can better diagnose intrauterine infection of premature rupture of membranes, and may also predict the prognosis of premature rupture of membranes in pregnant women.
【作者单位】：浙江大学医学院附属妇产科医院;浙江省温岭市第一人民医院妇产科;浙江省台州市台州医院病理科;浙江省金华市妇幼保健院妇产科;
【基金】：浙江省中医药科学研究计划(A类)基金资助项目(2010ZA103)
【分类号】：R714.433

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