子宫平滑肌腺瘤样瘤8例临床病理分析

发布时间：2018-05-21 12:27

本文选题：子宫肿瘤 + 平滑肌腺瘤样瘤　；参考：《临床与实验病理学杂志》2015年01期

【摘要】：目的探讨子宫平滑肌腺瘤样瘤(leiomyoadenomatoid tumour of uterine,LATU)的命名、临床病理学特征、诊断及鉴别诊断。方法回顾性分析8例LATU的临床资料、病理学及免疫表型特征,并复习相关文献。结果患者年龄39~52岁,平均45岁。眼观:LATU类似子宫平滑肌瘤,肿瘤直径1.2~6 cm,平均2.5 cm。6例肿瘤界限清楚,2例界限不清,切面灰白色,实性,质均,1例切面可见微囊。镜下见肿瘤性增生的平滑肌组织中混杂有大小形态不一的腺样腔隙,腔隙内衬扁平或立方上皮细胞,大多内衬上皮不明显。免疫表型:腺瘤样瘤细胞表达Calretinin、HBME-1、D2-40,不表达CD31和CD34。平滑肌细胞表达SMA。上皮样细胞和平滑肌细胞Ki-67增殖指数均1%。术后随访无复发或恶变。结论 LATU是由肿瘤性平滑肌和间皮组织构成的良性混合性肿瘤,其生物学行为呈良性,预后良好。
[Abstract]:Objective to investigate the nomenclature, clinicopathological features, diagnosis and differential diagnosis of leiomyoadenomatoid tumour of uterine leiomyoma. Methods the clinical data, pathological and immunophenotypic features of 8 cases of LATU were analyzed retrospectively. Results the age of the patients was 3952 years (mean 45 years). The diameter of the tumor was 1.2 ~ 6 cm, and the tumor boundary was clear in 2 cases (2.5 cm.6). The cut surface was grayish white, solid, and microencapsulated in 1 case. Under microscope, the smooth muscle tissue of neoplastic hyperplasia was mixed with glandular space of different size and shape, the space was lined with flat or cubic epithelial cells, and most of the inner lining epithelium was not obvious. Immunophenotype: Calretinin tumor cells expressed CD31 and CD34, but not CD31 and CD34. SMA was expressed in smooth muscle cells. The Ki-67 proliferation index of both epithelioid cells and smooth muscle cells was 1. There was no recurrence or malignant change during postoperative follow-up. Conclusion LATU is a benign mixed tumor composed of tumor smooth muscle and mesothelial tissue. Its biological behavior is benign and its prognosis is good.
【作者单位】：三峡大学仁和医院病理科;
【分类号】：R737.33

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